Apr 6, 2024 · Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue...

Nov 8, 2022 · lubac是目前唯一已知的可以催化形成线性泛素链的泛素连接酶复合物，由hoip、hoil-1和sharpin组成。lubac重要组分的基因缺失会引起严重的免疫功能障碍或者胚胎致死。

Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue...

Oct 20, 2013 · They are synthesized by HOIP, which belongs to the RBR (RING-between-RING) family of E3 ligases and is the catalytic component of LUBAC (linear ubiquitin chain assembly complex), a multisubunit...

近日，一项来自华中科技大学和郑州大学的研究揭示了 HOIP （HOIL-1-interacting protein）基因中一个罕见的移码变异如何显著影响人体的免疫系统，为我们理解免疫缺陷疾病提供了新的视角。 这项研究不仅深入剖析了变异对线性泛素化过程的影响，还巧妙地揭示了细胞死亡与免疫调控之间的微妙平衡。 本文将带您走进这项引人入胜的研究，感受科研的魅力与深度。 线性泛素链组装复合体（LUBAC）是细胞中唯一能够形成线性泛素链的E3泛素连接酶复合体，由HOIP、 HOIL …

Oct 3, 2017 · In this study, we present the crystal structure of SHARPIN UBL in complex with HOIP UBA domain and uncover the molecular mechanism underpinning the specific interaction between SHARPIN and HOIP.

Sep 1, 2021 · HOIP protects tumor cells from apoptosis induced by combined TNF and IFN‐γ co‐secreted by NK and CD8+ T cells. HOIP inhibition might thus be a strategy to enhance immunotherapy responses.image

Apr 15, 2024 · 通过质谱技术，研究团队获得了高质量的hoip相互作用数据集，每个域在每个组织中平均获得了约90个相互作用蛋白质。 这一研究为我们提供了一个全面的HOIP相互作用资源，有助于我们更好地理解线性泛素化在各个组织中的功能，并且揭示了组织功能与遗传性 ...

Nov 4, 2021 · Both genetic deletion and pharmacological inhibition of HOIP augment tumor cell sensitivity to combined TNF and IFN-γ. Together, we unveil a protective regulatory axis, involving HOIP, which limits a transcription-dependent form of cell death that engages both intrinsic and extrinsic apoptotic machinery upon exposure to TNF and IFN-γ.

利用生物化学分析技术对目的蛋白的结构及生物学性质进行表征，阐明了hoip、sharpin与hoil-1l之间的作用关系，同时也揭示了二硫键对uba结构域结构和生物学性质的影响。