2024年12月1日 · Transcription factors (TFs) are major contributors to gene transcription, especially in controlling cell-specific gene expression and disease occurrence and development. Uncovering the relationship between TFs and their target genes is critical to understanding the mechanism of action of TFs.

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This database of transcription factor (TF) to target gene interactions was constructed to facilitate construction of gene regulatory networks. It has been validated for this purpose and preforms quite well, please see Construction and Validation and Optimal Promoter Size for more information. Need help?

We provide the TF target gene predictions as separate CSV files for each TF motif. We also provide a conversion file that maps motif names to their cognate TF. Need help? Please contact cplaisier (at)systemsbiology.org if you have any questions, comments or concerns.

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