2021年2月16日 · Hoogsteen base pairs, the non-Watson–Crick base pairs, contain important hydrogen-bond patterns that form the helices of nucleic acids, such as in Watson–Crick base pairs, and can form non-double helix structures such as triplexes and quadruplexes.

A characteristic feature of Hoogsteen base pairing is that the N7 position of the purine is base-paired, altering the chemical reactivity of this position. A reverse Hoogsteen base pair involves flipping one of the bases 180° with respect to the other.

2022年12月23日 · In contrast to Watson-Crick (WC) base pairing, Hoogsteen (HG) base pairing involves flipping a purine base 180° between its anti and syn conformation. Recent studies have shown that HG...

There is now little doubt that Hoogsteen base-pairs exist in significant abundance in genomic DNA where they can expand the structural and functional versatility of duplex DNA beyond that which can be achieved based only on Watson-Crick base-pairing.

2014年9月4日 · Hoogsteen (HG) base pairing involves a 180° rotation of the purine base relative to Watson–Crick (WC) base pairing within DNA duplexes, creating alternative DNA conformations that can play...

2015年4月4日 · Hoogsteen (HG) base pairs (bps) provide an alternative pairing geometry to Watson–Crick (WC) bps and can play unique functional roles in duplex DNA. Here, we use structural features unique to HG bps ( syn purine base, HG hydrogen bonds and constricted C1′–C1′ distance across the bp) to search for HG bps in X-ray structures of DNA ...

2006年4月28日 · Recent experiments provide compelling evidence that Hoogsteen base pairs manifest in a gamut of nuclear processes encompassing gene expression, replication, recombination, and telomere length maintenance.

The A·U (or A·T) Hoogsteen pair is a well-known type of base pair (bp), named after the scientist who discovered it. As shown in the Figure below (left), in the Hoogsteen bp scheme, adenine uses its N7 (acceptor) and N6 (donor) atoms at the major groove edge to form two H-bonds with the N3 (donor) and O4 (acceptor) atoms from uracil ...

2002年12月1日 · Hoogsteen base pairs within duplex DNA typically are only observed in regions containing significant distortion or near sites of drug intercalation. We report here the observation of a Hoogsteen base pair embedded within undistorted, unmodified B-DNA.

2020年2月7日 · Non-canonical transient Hoogsteen (HG) base pairing is argued to facilitate DNA repair by assisting proteins and drugs in recognizing damaged regions of DNA.