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Quinolone antibiotic - Wikipedia
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. [2]
Quinolones - StatPearls - NCBI Bookshelf
May 22, 2023 · Quinolones are bactericidal antibiotics that directly kill bacterial cells. They act on bacterial type II topoisomerases, DNA gyrase, and topoisomerase IV, inhibiting their function and converting them into toxic enzymes that produce permanent double-stranded breaks in the bacterial chromosome.
Mechanism of Quinolone Action and Resistance | Biochemistry
Feb 27, 2014 · This review describes the development of the quinolones as antibacterials, the structure and function of gyrase and topoisomerase IV, and the mechanistic basis for quinolone action against their enzyme targets.
Quinolone - an overview | ScienceDirect Topics
Work on quinolone antibiotics goes back to the late 1960s when nalidixic acid was introduced into clinical practice. It had only moderate activity against Gram-negative bacteria and no activity against Gram-positive organisms and pseudomonads.
Quinolones: Mechanism, Lethality and Their Contributions to …
Dec 1, 2020 · Answering all these fundamental questions will help us to better understand how quinolones work and what specific components of their lethality and repair pathways should be targeted in order to avoid the appearance of quinolone and non-quinolone resistance.
Quinolones: from antibiotics to autoinducers - PMC - PubMed …
Quinolone antibiotics act by inhibiting the two type IIA bacterial topoisomerases: DNA gyrase and topoisomerase IV (bacterial type IIA topoisomerases have been reviewed recently by Sissi & Palumbo, 2010). DNA gyrase is a heterotetramer formed by two subunits encoded by gyrA (nalA) and gyrB (nalC).
Quinolone antibiotics - PMC - National Center for Biotechnology …
Nowadays, quinolones are widely used for treating a variety of infections. Quinolones are broad-spectrum antibiotics that are active against both Gram-positive and Gram-negative bacteria, including mycobacteria, and anaerobes.
Mechanism of quinolone action and resistance - PubMed
Mar 18, 2014 · This review describes the development of the quinolones as antibacterials, the structure and function of gyrase and topoisomerase IV, and the mechanistic basis for quinolone action against their enzyme targets.
Mechanism of Quinolone Action - Journal of Biological Chemistry
Quinolones could therefore act in a similar manner with the bacterial enzymes to enhance the rate of DNA strand cleavage.
The Quinolones: Past, Present, and Future - Oxford Academic
Jul 15, 2005 · Substantial progress has been made in our understanding of the molecular mechanisms of the action of quinolones against pathogenic bacteria, the induction of resistance to quinolones in these organisms, and the potential of each quinolone compound to induce toxicity in treated patients.