The Hox genes are a set of transcription factor genes that exhibit an unusual property: They provide a glimpse of one way in which gene expression is translated into the many different …

Hox genes play many more roles in vertebrate development. They help specify the difference between an arm and a leg, as well as a pinky and a thumb. In the nervous system, their …

Indeed, one of the most remarkable pieces of evidence for deep homologies among all the animals of the world is provided by the Hox genes. As mentioned in Chapter 11, not only are …

A Hox gene is defined as an evolutionary homologue of transcription factor genes found in all vertebrates, with multiple complexes in mammals. These genes exhibit colinearity in their …

Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. Hox genes are unique because they are spatially and …

2025年2月11日 · Hox genes, a subset of homeotic genes, are integral to the genetic framework determining an organism’s body plan during embryonic development. Highly conserved across …

2014年1月1日 · Human HOX disorders show variation in inheritance, pathogenesis and expressivity. We review phenotypes, inheritance and molecular genetics of human HOX …

2024年11月20日 · We analyse HOX gene expression across cell types during development, finding that neural-crest derivatives unexpectedly retain the anatomical HOX code of their …

2023年1月1日 · Here, we provide an overview of Hox genes, highlighting their evolutionary history, their unique genomic organization and how this impacts the regulation of their …

In this commentary, we highlight recent reports that have provided novel insight into the origins of the mammalian Hox cluster, the role of Hox genes in the generation of a limbless body plan, …