HOX gene expression in the developing human spine - Nature
2024年11月20日 · Examining cells expressing the neural crest markers MSX1, FOXD3, SNAI1, SNAI2, SOX5, SOX8, SOX10 and ETS1, we observed expression of the thoracic HOX code, in addition to the cervical gene...
Hox Genes: Choreographers in Neural Development
2013年10月2日 · The spinal cord can be classified into cervical, thoracic, lumbar, and sacral regions, based on the segmental position of vertebrae, as well as the organization of motor and sensory nerve roots.
HOX gene expression in the developing human spine - PMC
The HOX gene cluster is responsible for anteroposterior axis patterning in an evolutionarily conserved manner. Here they examine HOX gene expression in human embryos and show that neural-crest derivatives retain the anatomical HOX code of their origin while also adopting the code of their destination. Introduction
Protogenin facilitates trunk-to-tail HOX code transition via …
During gastrulation, activation of the Wnt signaling in NMPs induces the expression of anterior Hox genes Hox1 to Hox5 13, which define the cervical and anterior thoracic vertebrae.
Hox Gene - an overview | ScienceDirect Topics
Hox genes are members of the homeotic transcription factor family that play a key role in controlling the body plan along the cranio-caudal axis (also referred to as anterior–posterior), and specify segment identity of tissues within the embryo.
Hox Genes in Development: The Hox Code | Learn Science at …
On the left side of the panel, a diagram of the axial skeleton is shown, with specific vertebral elements shown in the right panel marked (C, cervical; T, thoracic; L, lumbar, S, sacral)....
Hox Genes: Choreographers in Neural Development, Architects …
The spinal cord can be classified into cervical, thoracic, lumbar, and sacral regions, based on the segmental position of vertebrae, as well as the organization of motor and sensory nerve roots.
Hox genes and regional patterning of the vertebrate body plan
2010年8月1日 · The possibility that HoxPG6 genes are involved in the specification of the boundary between cervical and thoracic regions was initially suggested by studies showing that their anterior limits of expression in the paraxial mesoderm correlated with the cervical to thoracic transition rather than to absolute somite number in vertebrate species ...
Hox Genes - Transcriptional Control of Neural Crest Development …
Hox transcription factors are a conserved family of homeobox-containing proteins related to Drosophila homeotic Hom-C proteins. Across metazoan species, Hox genes are important for anterior-to-posterior patterning, and the organization of Hox genes within the genome correlates with their anterior-to-posterior expression within the body plan.
Boundaries between Hox gene expression define body regions (seen clearly in axial skeleton). Regions of Hox gene expression in mammals vs. birds are consistent with differences in numbers of vertebral types. For example, the boundary between cervical and thoracic vertebrae is marked by the Hox group 5 and 6 boundary.