Homeodomain proteins profoundly contribute to liver regeneration. Hox genes serve as either oncogenes or tumor suppressor genes during target organ carcinogenesis. However, to date, no study investigated whether PFCs regulate expression of Hox genes.

2018年12月13日 · HOXA10 was the most highly expressed HOX transcription factor in liver cancer and liver TICs. LncHOXA10 drove the transcriptional activation of HOXA10. This work revealed the important role of HOX transcription factor in liver TIC self-renewal and added a new layer for liver TIC regulation.

(1) HOX Genes and Hematopoietic Stem Cells. Hematopoietic stem cells (HSCs) are generally found in the bone marrow but can also be isolated from the peripheral blood, umbilical cord blood, and fetal liver. HOX genes are expressed in HSCs and progenitors in a lineage-specific and differentiation stage-restricted manner.

2020年2月1日 · HOX genes encode a highly evolutionarily conserved family of homeodomain-containing transcription factors found in nearly all eukaryotic cells. The homeobox genes were originally discovered in a study of Drosophila melanogaster embryo development [1], with mutations in ultrabithorax and antennapedia observed to cause abnormal body formation ...

2011年12月1日 · Liver organogenesis and cancerogenesis share common mechanisms. HOX genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. Less is known about the involvement of HOX genes with liver cancerogenesis.

2012年12月5日 · Analysis of Hox gene expression in fetal liver cells (c-Kit + Hoxb1-Hoxb9 −/−), revealed genetic interactions between members of the Hoxa, b and c clusters, whereby these cells exhibited ...

The homeobox B13 (HOXB13) gene, a member of HOX family, plays diverse biological roles in embryonic development, carcinogenesis, and many inflammatory diseases. However, the expression of HOXB13 in chronic liver diseases including hepatic fibrosis remains to be defined.

There is also growing evidence that HOXA13 has a role in liver cancer. HOXA13 is over-expressed in primary hepatocellular carcinoma (HCC) and is strongly associated with hepatitis B and C virus infection.

HOXA genes, a specific subset within the HOX family, have received significant attention in the fields of organ development, disease pathogenesis, and various cancer types. These genes have been identified as crucial players in cancer progression, acting both as oncogenes and inhibitors.

2021年2月24日 · Induction of HOX genes by the core protein may be the first step of host regulation associated with hepatitis C-related liver disorders. Acetylation of histone H3K27 has been reported to be altered by HCV infection in patients’ liver, independent of indirect factors such as the inflammatory response and fibrosis, and these changes persist ...