
Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver
Homeodomain proteins profoundly contribute to liver regeneration. Hox genes serve as either oncogenes or tumor suppressor genes during target organ carcinogenesis. However, to date, no study investigated whether PFCs regulate expression of Hox genes.
LncHOXA10 drives liver TICs self-renewal and tumorigenesis via …
2018年12月13日 · HOXA10 was the most highly expressed HOX transcription factor in liver cancer and liver TICs. LncHOXA10 drove the transcriptional activation of HOXA10. This work revealed the important role of HOX transcription factor in liver TIC self-renewal and added a new layer for liver TIC regulation.
Role of HOX Genes in Stem Cell Differentiation and Cancer
(1) HOX Genes and Hematopoietic Stem Cells. Hematopoietic stem cells (HSCs) are generally found in the bone marrow but can also be isolated from the peripheral blood, umbilical cord blood, and fetal liver. HOX genes are expressed in HSCs and progenitors in a lineage-specific and differentiation stage-restricted manner.
HOX family transcription factors: Related signaling pathways …
2020年2月1日 · HOX genes encode a highly evolutionarily conserved family of homeodomain-containing transcription factors found in nearly all eukaryotic cells. The homeobox genes were originally discovered in a study of Drosophila melanogaster embryo development [1], with mutations in ultrabithorax and antennapedia observed to cause abnormal body formation ...
The HOX gene network in hepatocellular carcinoma - PubMed
2011年12月1日 · Liver organogenesis and cancerogenesis share common mechanisms. HOX genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. Less is known about the involvement of HOX genes with liver cancerogenesis.
The role of HOX genes in normal hematopoiesis and acute leukemia
2012年12月5日 · Analysis of Hox gene expression in fetal liver cells (c-Kit + Hoxb1-Hoxb9 −/−), revealed genetic interactions between members of the Hoxa, b and c clusters, whereby these cells exhibited ...
HOXB13 expression is correlated with hepatic inflammatory
The homeobox B13 (HOXB13) gene, a member of HOX family, plays diverse biological roles in embryonic development, carcinogenesis, and many inflammatory diseases. However, the expression of HOXB13 in chronic liver diseases including hepatic fibrosis remains to be defined.
Paralogous HOX13 Genes in Human Cancers - PMC
There is also growing evidence that HOXA13 has a role in liver cancer. HOXA13 is over-expressed in primary hepatocellular carcinoma (HCC) and is strongly associated with hepatitis B and C virus infection.
Role of HOXA1-4 in the development of genetic and malignant …
HOXA genes, a specific subset within the HOX family, have received significant attention in the fields of organ development, disease pathogenesis, and various cancer types. These genes have been identified as crucial players in cancer progression, acting both as oncogenes and inhibitors.
Induction of HOX Genes by Hepatitis C Virus Infection via …
2021年2月24日 · Induction of HOX genes by the core protein may be the first step of host regulation associated with hepatitis C-related liver disorders. Acetylation of histone H3K27 has been reported to be altered by HCV infection in patients’ liver, independent of indirect factors such as the inflammatory response and fibrosis, and these changes persist ...