Homeodomain proteins profoundly contribute to liver regeneration. Hox genes serve as either oncogenes or tumor suppressor genes during target organ carcinogenesis. However, to date, …

2018年12月13日 · HOXA10 was the most highly expressed HOX transcription factor in liver cancer and liver TICs. LncHOXA10 drove the transcriptional activation of HOXA10. This work …

(1) HOX Genes and Hematopoietic Stem Cells. Hematopoietic stem cells (HSCs) are generally found in the bone marrow but can also be isolated from the peripheral blood, umbilical cord …

2020年2月1日 · HOX genes encode a highly evolutionarily conserved family of homeodomain-containing transcription factors found in nearly all eukaryotic cells. The homeobox genes were …

2011年12月1日 · Liver organogenesis and cancerogenesis share common mechanisms. HOX genes control normal development, primary cellular processes and are characterized by a …

2012年12月5日 · Analysis of Hox gene expression in fetal liver cells (c-Kit + Hoxb1-Hoxb9 −/−), revealed genetic interactions between members of the Hoxa, b and c clusters, whereby these …

The homeobox B13 (HOXB13) gene, a member of HOX family, plays diverse biological roles in embryonic development, carcinogenesis, and many inflammatory diseases. However, the …

There is also growing evidence that HOXA13 has a role in liver cancer. HOXA13 is over-expressed in primary hepatocellular carcinoma (HCC) and is strongly associated with hepatitis …

HOXA genes, a specific subset within the HOX family, have received significant attention in the fields of organ development, disease pathogenesis, and various cancer types. These genes …

2021年2月24日 · Induction of HOX genes by the core protein may be the first step of host regulation associated with hepatitis C-related liver disorders. Acetylation of histone H3K27 has …