Hox transcription factors and their elusive mammalian gene …
2006年5月24日 · In order to better understand Hox transcriptional specificity, we examined the identified Hox binding motifs of the mammalian targets in an effort to characterise base pair …
关于Hox genes：从果蝇说起 - 知乎 - 知乎专栏
homeobox genes的子集——HOX genes（只在动物中发现）复制后成为HOX clusters. HOX gene 突变后产生homeotic mutations，影响动物形态发育. 同源异型基因（英语：homeotic …
The human HOXA9 protein uses paralog-specific residues of …
2019年4月5日 · Here we dissected TALE interaction properties of the human posterior HOXA9 protein, which is characterized by the presence of a divergent HX motif when compared to …
Multimodal Hox5 activity generates motor neuron diversity - Nature
2024年9月17日 · Hox proteins bind DNA through their homeodomain, a 60 amino acid domain that recognizes a short TA-rich DNA motif. Homeobox domains are highly similar among …
HOX family transcription factors: Related signaling pathways …
2020年2月1日 · HOX family transcription factors play key roles in numerous cellular processes including cell growth, differentiation, apoptosis, motility, and angiogenesis. As tumor promoters …
Variable motif utilization in homeotic selector (Hox)–cofactor …
Homeotic selector (Hox) proteins often bind DNA cooperatively with cofactors such as Extradenticle (Exd) and Homothorax (Hth) to achieve functional specificity in vivo. Previous …
The Hox protein conundrum: The “specifics” of DNA binding for Hox ...
Many HOX proteins contain a conserved hexapeptide motif containing tyrosine (Y)-proline (P)-tryptophan (W)-methionine (M) in series (YPWM). The importance of this motif varies in …
HOX paralogs selectively convert binding of ubiquitous ... - PLOS
2020年12月14日 · We identify three main determinants of HOX paralog-selective binding: recognition of unique variants of the HOX-PBX motif, differential affinity at shared HOX-PBX …
Human HOX Proteins Use Diverse and Context-Dependent
2018年3月13日 · Here, we present a systematic analysis of HOX/PBX/MEIS interaction properties, scanning all paralog groups with human and mouse HOX proteins in vitro and in …
Residues Flanking the HOX YPWM Motif Contribute to …
1997年7月25日 · Previously, we have shown that HOXD4 and PBX1A cooperatively bind DNA through a motif present in HOX proteins called the pentapeptide or YPWM motif (17). This …