Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in response to pregnancy.

In vivo, lethally irradiated mice with transplanted HOXA9 knockout HSCs displayed a 4-fold to 12-fold reduction in repopulating ability. Furthermore, they developed 60% less myeloid and erythroid colonies in the bone marrow when compared to the wild type. [14] .

In mouse cell models, HXR9 affects cell survival of murine hematopoietic progenitor cells transduced with MLL-AF9 or with both HOXA9 and PBX3. Interestingly, HXR9 reduced cell viability in a variety of HOXA7/9/11-positive cell line and blasts from patients but not on HOXA7/9/11-negative ones.

2019年3月14日 · In this report we show that the Hoxa9,10,11, Hoxc9,10,11, Hoxd9,10,11 genes play a redundant role in the formation of uterine glands. In addition, we use single cell RNA-seq to create a high...

2015年7月19日 · The Hoxa9,10,11 −/− /Hoxd9,10,11 −/− mutant mice show a reduced ulna and radius that is more severe than seen in Hoxa11 −/− /Hoxd11 −/− mice, indicating a minor role for the flanking Hox9,10 genes in zeugopod development, as well as their primary

2024年12月25日 · HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include Leukemia, Acute Lymphoblastic and Hematologic Cancer. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HMX3.

2015年7月19日 · The Hoxa9,10,11 (-/-) /Hoxd9,10,11 (-/-) mutant mice show a reduced ulna and radius that is more severe than seen in Hoxa11 (-/-)/Hoxd11 (-/-) mice, indicating a minor role for the flanking Hox9,10 genes in zeugopod development, as well as their primary function in stylopod development.

1999年1月19日 · Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in response to pregnancy.

View mouse Hoxa9 Chr6:52200077-52203169 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous genes are required for mediating the expansion and/or differentiation of the mammary epithelium ductal system in response to pregnancy.