2024年12月25日 · HOXA3 (Homeobox A3) is a Protein Coding gene. Diseases associated with HOXA3 include Familial Thyroid Dyshormonogenesis and Penile Cancer. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

3200 15400 Ensembl ENSG00000105997 ENSMUSG00000079560 UniProt O43365 P02831 RefSeq (mRNA) NM_030661 NM_153631 NM_153632 NM_010452 RefSeq (protein) NP_109377 NP_705895 NP_034582 Location (UCSC) Chr 7: 27.11 – 27.15 Mb Chr 6: 52.15 – 52.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene. Function In ...

2010年12月19日 · We show here that HoxA3, a gene uniquely expressed in the embryonic but not yolk sac vasculature, restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces...

2024年1月8日 · Our results demonstrated that HOXA3 functioned as the on-off switch to regulate the development of hESC-derived 3PPE through EPHB2-mediated Wnt pathway, and our findings will provide new insights into studying the development of …

HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway. Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression.

2023年4月6日 · Results: We report that transcription factor homeobox A3 (HOXA3), which is aberrantly highly expressed in glioblastoma (GBM) patients and predicts poor prognosis, transcriptionally activates aerobic glycolysis, leading to a significant acceleration in cell proliferation and tumor growth.

在脊椎动物中，编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。 这些蛋白质的表达在胚胎发育过程中受到时空调控。 该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。 已发现该基因编码两种不同亚型的三种转录变体。 [RefSeq 提供，2008 年 7 月] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on …

We show here that HoxA3, a gene uniquely expressed in the embryonic but not yolk sac vasculature, restrains hematopoietic differentiation of the earliest endothelial progenitors, and reverts the earliest hematopoietic progenitors into CD41-negative endothelial cells.

HOXA3 exhibits distinct expression patterns within sub-domains of second heart field cells, which contribute to embryonic heart development during cardiac looping . The absence of the third arch artery, resulting in carotid artery system malformation, has been observed in homozygous HOXA3 mutants [ 45 , 46 ].

HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway. Homeobox A3 (HOXA3), one of HOX transcription factors, regulates gene expression during embryonic development.