2024年12月25日 · HOXA6 (Homeobox A6) is a Protein Coding gene. Diseases associated with HOXA6 include Foster-Kennedy Syndrome and Angiomatous Meningioma. Among its related pathways are Kidney development and Nervous system development.

HOXA6 was examined to be preferentially expressed in primitive cells (e.g. hematopoietic progenitor cells), under the regulation of growth factors and cell cycles. Interleukin 3 and all-trans retinoic acid were found to be the inducing factors that can stimulate the expression of HOXA6.

The present study aimed to investigate the role of homeobox A6 (HOXA6) in the proliferation and apoptosis of ccRCC cells. Analysis of the GSE6344 dataset and immunohistochemistry revealed that the mRNA and protein expression levels of HOXA6 were suppressed in ccRCC tissues.

2022年3月29日 · Emerging evidence has demonstrated that homeobox A cluster (HOXA) gene family plays a critical role in the transcriptional regulation as well as cancer initiation and progression. However, the expression, biological functions and upstream regulatory mechanism of 11 HOXAs in low grade glioma are not yet clear.

HOXA6 regulated apoptosis through the Bcl-2 signaling pathway, and regulated migration and invasion through the EMT process. HOXA6 is a signature gene involved in cell growth and sensitivity to chemotherapy in acute myeloid leukemia cells.

We uncover that HOXA6 was up-regulated in LGG cells lines, especially in SF295 and A172 cells. Depletion of HOXA6 significantly inhibits LGG cells proliferation and migration abilities. CONCLUSIONS. HOXAs participated in the progression of LGG and were differentially expressed in LGG tissues. HOXA6 may be potential biomarker for the diagnosis ...

2009年3月1日 · The potentiation of proliferation, autonomous growth, and self-renewal caused by overexpressed HOXA6 supports gene expression studies that identify HOXA6 as part of a leukemia-associated “HOX code” 18, 21, 22, 26, 58, 59, and provides functional insights into the role of Hoxa6 in hemopoiesis.

2021年2月1日 · In vivo, HOXA6 was shown to cooperate with PBX2 to enhance cell metastasis via orthotopic implantation. These data indicate that HOXA6 promotes cell proliferation, migration, and invasion and that the HOXA6-PBX2 axis may be a …

2006年11月16日 · HOXA6 was ranked, as the most highly expressed gene (range 1 x 103 – 2 x 107 copies per 50 ng RNA), substantially higher than HOXA9 (see Table). Further analysis identified high expression of HOXA6 in both human myeloid cell lines and CD34+ enriched primary progenitors.

在脊椎动物中，编码称为同源盒基因的转录因子类的基因位于四个独立染色体上名为 A、B、C 和 D 的簇中。 这些蛋白质的表达在胚胎发育过程中受到时空调控。 该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。 [RefSeq 提供，2008 年 7 月] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.