2024年12月25日 · HOXB1 (Homeobox B1) is a Protein Coding gene. Diseases associated with HOXB1 include Facial Paresis, Hereditary Congenital, 3 and Congenital Hereditary Facial Paralysis-Variable Hearing Loss Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

3211 15407 Ensembl ENSG00000120094 ENSMUSG00000018973 UniProt P14653 P17919 RefSeq (mRNA) NM_002144 NM_008266 RefSeq (protein) NP_002135 NP_032292 Location (UCSC) Chr 17: 48.53 – 48.53 Mb Chr 11: 96.26 – 96.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene. Function This gene belongs to the homeobox ...

哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，分别位于不同的染色体上，由 9～11 个串联排列的基因组成。 该基因是位于 17 号染色体簇中的几个同源框 HOXB 基因之一。 [RefSeq 提供，2008 年 7 月] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

2015年10月15日 · Here, we report that Hoxb1 deficiency results in a shorter OFT and ventricular septal defects (VSD). Mechanistically, we show that both FGF/ERK and BMP/SMAD signaling, which regulate proliferation and differentiation of cardiac progenitor cells and OFT morphogenesis, are enhanced in the pharyngeal region in Hoxb1 mutants.

2022年3月16日 · We found that Hoxb1 promotes NMP survival through the upregulation of Fgf8, Fgf17, and other components of Fgf signaling as well as the repression of components of the apoptotic pathway. Additionally, it upregulates other anterior Hox genes suggesting that it plays an active role in the early steps of AP specification.

2024年11月2日 · Title: HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma. The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1 (-/-) mouse phenotype. Title: HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice.

2018年3月1日 · HOXB1 is a member of the highly conserved homeobox (HOX) gene family, which encodes homeodomain-containing transcription factors that confer specificity of spatial-temporal patterning in vertebrates, Drosophila and C. elegans (summary by Webb et al., 2012).

2025年2月8日 · Hoxb1 is required for the anterior-posterior identity of precursors that contribute to the lateral vestibular nucleus. The results of this study show that ES neural differentiation and inducible Hox gene expression can be used as a sensitive model system to systematically identify Hox novel target genes.

2024年3月1日 · HOXB1 homeobox B1 Gene ID: 3211, updated on 1-Mar-2024 Gene type: protein coding Also known as: HOX2; HCFP3; HOX2I; Hox-2.9. See all available tests in GTR for this gene; Go to complete Gene record for HOXB1; Go to Variation Viewer for HOXB1 variants; Summary. This gene belongs to the homeobox family of genes.

We report that timely induction of a Hoxb1 transgene in ESC-derived NSCs resulted in the specification of NSCs toward a hindbrain-specific identity through the activation of a rhombomere 4-specific genetic program and the repression of anterior neural identity.