2024年12月25日 · HOXB2 (Homeobox B2) is a Protein Coding gene. Diseases associated with HOXB2 include Pancreatic Cancer and Leukemia, Acute Myeloid. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene. [5][6][7] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17.

2024年1月20日 · We found that the reduced expression of HOXB2 was correlated with the metastatic abilities (epithelial-to-mesenchymal transition) of TNBC cells. Further, we revealed that HOXB2 restrained TNBC aggressiveness by ECM organization. HOXB2 bound to the promoter regions of MATN3 and ECM2 and regulated their transcription levels. Forced expression of ...

2024年1月20日 · HOXB2 bound to the promoter regions of MATN3 and ECM2 and regulated their transcription levels. Forced expression of HOXB2 effectively prevented TNBC progression and metastasis in a mouse xenograft model. Reduction of HOXB2 and the HOXB2/MATN3/ECM2 transcriptional axis correlated with poor survival in patients with various cancers. Further, we ...

Hoxb2, Hoxb5, Hoxb7, and Hoxc4 genes were found to regulate self-renewal and differentiation of murine MSCs . HOX genes have been shown to play critical roles during osteogenesis of human MSCs. Histone demethylase KDM6B controlled HOX expression by removing histone 3K27 trimethylation (H3K27me3) and reduced KDM6B significantly by reducing ...

Hoxb2 is a direct target for regulation by PLZF in the developing CNS and suggest that deregulation of Hox gene expression may contribute to APL pathogenesis. This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17.

2020年5月26日 · The top five HOX genes most associated with genomic instability and DNA repair pathways after the enrichment analysis were HOXC12, HOXC11, HOXC5, HOXB2, and HOXA9 . Although there is good evidence that these HOX genes are involved in cancer development, their role in DNA repair and genomic instability is presently unknown.

2023年10月10日 · HOXB2 is a Putative Tumour Promotor in Human Bladder Cancer. Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.

2021年8月20日 · Using a mouse model and human breast cancer cell lines, we show that estrogen suppresses HOXB2 expression. Suppression of HOXB2 by PPT, a known ERα agonist, in MCF-7 and T47D cells indicated the involvement of ERα, which was confirmed by siRNA-mediated ERα knockdown experiments.

它包含在位于 17 号染色体上的同源框 B 基因簇中。 编码的蛋白质作为参与发育的序列特异性转录因子发挥作用。 该基因表达增加与胰腺癌有关。 [RefSeq 提供，2008 年 7 月] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17.