2024年12月25日 · HOXB8 (Homeobox B8) is a Protein Coding gene. Diseases associated with HOXB8 include Trichotillomania and Impulse Control Disorder. Among its related pathways is Fragile X syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding.

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene. [5][6][7] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17.

2025年2月8日 · Bioinformatics and Luciferase method screened HOXB8 as a downstream regulatory target of miR-32-5p. Besides, HOXB8 was incredibly highly expressed in CCa tissues and cells. Decreased expression of HOXB8 resulting from upregulation of miR-32-5p could weaken cell proliferation, clone formation, invasion and migration ability of HeLa cells.

2006年3月22日 · Using knockout or small interfering RNA (siRNA) technologies, this ER-Hoxb8 phagocyte maturation system represents a rapid analytical tool for studying macrophage and neutrophil biology.

2023年4月10日 · Herein we show, that optogenetic stimulation of Hoxb8 microglia in specific regions of the brain induces elevated anxiety, grooming or both.

2022年4月15日 · Our murine cell lineage analysis shows that the Hoxb8 cell lineage reporter robustly marks erythromyeloid progenitors, hematopoietic stem cells and their progeny, particularly monocytes. Hoxb8 progenitors and microglia require Myb function, a hallmark transcription factor for definitive hematopoiesis, for propagation and maturation.

首先，作者使用了一种体外分化系统，在该系统中，原代小鼠骨髓（BM）祖细胞通过 Hoxb8-雌激素受体融合基因永生，并在β-雌二醇去除后诱导分化。先前的研究表明，Hoxb8-永生化细胞（以下简称 "HOXB8 细胞 "）可在体外和体内分化为功能性中性粒细胞。按照 Flynn ...

用雌激素受体-Hoxb8 转录因子融合构建体进行转导，有条件地使能够分化为中性粒细胞的骨髓祖细胞 (NeutPro) 永生化。 该系统对于产生大量小鼠中性粒细胞用于体外和体内研究非常有用。

2023年11月23日 · It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer.

该基因是 Antp 同源框家族的成员，编码具有同源框 DNA 结合域的核蛋白。 它包含在位于 17 号染色体上的同源框 B 基因簇中。 编码的蛋白质作为参与发育的序列特异性转录因子发挥作用。 该基因表达增加与结直肠癌有关。 敲除该基因的小鼠直系同源物的小鼠表现出过度的病态梳理行为。 这种行为类似于患有强迫症拔毛癖的人类的行为。 [RefSeq 提供，2008 年 7 月] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA …