HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of SIR (silent information regulatory) proteins serve a similar function.

Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the ...

异染色质蛋白1（Heterochromatin Protein 1 ，HP1），与多梳硫质蛋白（CBX）同源，是高度保守的蛋白质，在细胞核中具有重要的作用。 这些功能包括异染色质形成、转录激活基因的表达，对衔接配合的着丝粒结合调控，序列基因转录的核外围，逮捕，异染色质的完整性维护，在单核小体水平和异染色质化常染色质基因阻遏基因的表达 [1]。 HP1蛋白是在几乎所有的 真核细胞 染色体着丝粒和端粒与 芽殖酵母 中存在的，其中SIR的特定酵母沉默复合物（沉默信息调节）的蛋白 …

Heterochromatin Protein 1 (HP1) is a transcriptional repressor that directly binds to the methylated lysine 9 residue of histone H3 (H3K9me), which is a hallmark histone modification for transcriptionally silenced heterochromatin.

2024年11月7日 · Heterochromatin protein 1 (HP1) plays a central role in establishing and maintaining constitutive heterochromatin. However, the mechanisms underlying HP1-nucleosome interactions and their contributions to heterochromatin functions remain elusive.

Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.

2021年6月9日 · Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromatin protein HP1α (CBX5) is unknown. We used a novel HP1α auxin-inducible degron human cell line to rapidly degrade HP1α.

2018年2月1日 · Here we report the three-dimensional structure of the H3K9me3-containing dinucleosomes complexed with human HP1α, HP1β, and HP1γ, determined by cryogenic electron microscopy with a Volta phase plate. In the structures, two H3K9me3 nucleosomes are bridged by a symmetric HP1 dimer.

2019年10月16日 · The S. pombe HP1 protein Swi6 couples chromatin compaction to phase separation by dynamically exposing buried histone residues within nucleosomes. Heterochromatin affects genome function at many...

ISOCELL HP1 是一款支持 2 亿像素 的移动图像传感器。 它在 1/1.22” 光学格式中包含 2 亿个 0.64 微米大小的像素。 ISOCELL HP1 可根据拍摄环境使用三种不同的像素布局。 为了利用 2 亿像素传感器的全部功能，该技术通过使用由深度学习算法提供支持的增强软件像素重排来重新排列像素阵列。 无论是电影般的旅行视频还是史诗般的慢动作剪辑，ISOCELL HP1 都能以精致的细节捕捉视频。 为了以较小的视野损失录制 8K 视频，ISOCELL HP1 将 4 个像素合二为一，形成一个 …