2021年4月14日 · Here, by combining chromosome conformation capture (Hi-C), chromatin immunoprecipitation with high-throughput sequencing (ChIP–seq), 3D DNA fluorescence in situ hybridization (3D DNA FISH) and...

2023年9月12日 · By analyzing publicly available ChIP-seq data for HP1 and SETDB1, we found that significant enrichment of HP1γ, but not HP1α and HP1β, were observed at SETDB1-bound genes (Figure S4A). A GO analysis revealed that HP1γ-SETDB1 co-bound genes were strongly associated with germ-line development (meiosis and spermatogenesis).

2018年5月23日 · Here we show that ADNP interacts with the chromatin remodeller CHD4 and the chromatin architectural protein HP1 to form a stable complex, which we refer to as ChAHP. Besides mediating complex...

2015年2月24日 · HP1 regulates this gene’s alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form. Our results demonstrate DNA methylation’s significant global influence on mRNA splicing and identify a specific mechanism of splicing regulation mediated by HP1.

他们通过结合 染色体构象捕获 （Hi-C）、染色质免疫沉淀和 高通量测序 （ChIP–seq）、3D-DNA 荧光原位杂交 （3D-DNA-FISH）和聚合物模拟，发现异染色质蛋白1a（HP1a）在果蝇早期发育过程中对从头建立三维基因组是必不可少的。他们发现HP1a的结合丝粒周围异染色质 ...

2016年4月19日 · Here we demonstrate that human HP1β is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. These are caused by dimeric and dynamic interaction with highly enriched...

HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear.

Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene regulation through a variety of molecular mechanisms. HP1 proteins are highly conserved, and many eukaryotic genomes contain multiple HP1 …

2024年5月24日 · HP1’s self-association and phase-separating properties, and its binding to methylated H3K9, make it a prime candidate to be a determinant of genome compartmentalization. However, the in vivo roles of HP1 and …

2015年9月28日 · Here we identify Heterochromatin Protein 1β (HP1β) as an essential protein for proper differentiation, and, unexpectedly, for the maintenance of pluripotency in ESCs. In pluripotent and differentiated cells HP1β is differentially localized …