2015年2月24日 · HP1 regulates this gene’s alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form. Our results demonstrate DNA methylation’s significant global influence on mRNA splicing and identify a specific mechanism of splicing regulation mediated by HP1.

2008年8月8日 · Mammalian heterochromatin protein 1 isoforms HP1α, HP1β, and HP1γ play important roles in the regulation of chromatin structure and function. We explored the possibility of different roles for the three HP1 isoforms in an integrated …

2022年12月19日 · HP1 proteins prevent aberrant association between PCH and nucleoli. Given the prominent role of HP1α/β proteins in heterochromatin formation at PCH (Figure 1) (35, 36, 41–44, 46), we investigated the role of PCH in nucleolar deformation in mutant cells.

2019年10月16日 · The S. pombe HP1 protein Swi6 couples chromatin compaction to phase separation by dynamically exposing buried histone residues within nucleosomes. Heterochromatin affects genome function at many...

To gain insight in the role of the RNA‐binding activity of HP1γ in transcriptionally active chromatin, we have captured and analysed RNAs associated with this protein. We find that HP1γ is specifically targeted to hexameric RNA motifs and coincidentally transposable elements …

2015年9月28日 · Here we identify Heterochromatin Protein 1β (HP1β) as an essential protein for proper differentiation, and, unexpectedly, for the maintenance of pluripotency in ESCs. In pluripotent and differentiated cells HP1β is differentially localized …

We reveal that the specific affinity of HP1 for H3K9me2/3 loci facilitates coacervation in nucleo and promotes the formation of stable PCH condensates at HP1 levels far below the concentration required to observe phase separation in purified protein assays in vitro.

1 (HP1), a highly conserved non-histone chromosomal protein in eukaryotes, pl. ys important roles in the regulation of gene transcription. Each of the three human homologs of HP1 includes a chromoshadow domain (CSD). The CSD interacts with various proteins bearing the …

包含蛋白质 hp1 的复合物与特定的调控 dna 序列结合以促进基因组区域的局部压实基因组区域并抑制驱动特定细胞谱系分化的相关基因。 "点击查看英文标题和摘要"

2016年8月24日 · Targeting of HP1 proteins to specific chromatin locales is mediated, at least in part, by the HP1 chromodomain, which binds to histone H3 methylated at lysine 9 that marks condensed regions of the genome. Mechanisms that regulate HP1 targeting are emerging from studies with yeast and metazoans and point to roles for posttranslational modifications.