2024年12月25日 · HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Hematologic Cancer and Candidiasis. Among its related pathways are Resistance of ERBB2 KD mutants to osimertinib and Loss of proteins required for interphase microtubule organization from the centrosome.

Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins.

2010年6月4日 · Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity.

2016年6月23日 · Here, we developed a mass-spectrometry-based approach that allowed quantitative measurements of in vitro and in vivo effects of small-molecule inhibitors on Hsp90 conformation, and interaction with co-chaperones and client proteins.

由该基因编码的蛋白质是一种可诱导的分子伴侣，可作为同型二聚体发挥作用。 编码的蛋白质通过使用由辅助伴侣调节的 ATP 酶活性来帮助特定目标蛋白质的正确折叠。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2012 年 1 月] The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer.

2005年12月1日 · HSP90 proteins are important molecular chaperones. Transcriptome and genome analyses revealed that the human HSP90 family includes 17 genes that fall into four classes. A standardized nomenclature for each of these genes is presented here. Classes HSP90AA, HSP90AB, HSP90B, and TRAP contain 7, 6, 3, and 1 genes, respectively.

2016年， 国家食品药品监督管理总局 批准血浆热休克蛋白90α用作肝癌标志物。 Hsp90α是一种细胞质蛋白质，在生物进化过程中高度保守，约占细胞质蛋白的1%～2%。 [1] 肿瘤标志物是由肿瘤细胞合成、释放，或由机体在肿瘤细胞作用下产生的、能够反映肿瘤存在和生长的一类物质。 通常，它在肿瘤患者体内的含量远远超过健康人，在 肿瘤筛查 、诊断、判断预后、评价疗效和高危人群随访等方面都具有重要的实用价值。 肿瘤标志物检查简便易行，对身体伤害小，仅需要少 …

2015年10月1日 · Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins.

Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A view is emerging that identifies HSP90 not as one protein that is structurally and functionally homogeneous but, rather, as a protein that is shaped by its environment.

2016年6月23日 · We use three well-known Hsp90 inhibitors, 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), XL-888, and novobiocin, at varying concentrations and demonstrate that the technique allows quantification of crosslinked peptide pairs either by MS 1 based or targeted MS 2 (parallel reaction monitoring [PRM]) based methods.