2024年6月13日 · Patients with sepsis-related ARDS had reduced levels of HSP90AA1. However, whether the changes in CD8 + T cells were related to HSP90α, encoded by the HSP90AA1 gene, was unclear. This study aimed...

高侵袭性肿瘤细胞能够分泌大量Hsp90α，激活基质金属蛋白酶2 (MMP-2)进而诱导MMP-3的表达，驱动肿瘤侵袭，因此开发Hsp90α选择性抑制剂具有其独特意义。 Hsp90α和Hspβ亚型选择性抑制剂的设计极具挑战性，因为两种亚型在N端ATP结合位点上的同源性大于95%，且在ATP的核苷酸结合位点上仅有52位和91位两个氨基酸存在差异。

Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins.

2024年12月25日 · HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Hematologic Cancer and Candidiasis. Among its related pathways are Resistance of ERBB2 KD mutants to osimertinib and Loss of proteins required for interphase microtubule organization from the centrosome.

2010年6月4日 · Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity.

2016年6月23日 · Current critical challenges for effective Hsp90 cancer therapies involve developing small molecules that inhibit Hsp90 but do not lead to induction of HS90A, and other heat shock response elements.

2015年10月1日 · Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins.

2015年10月1日 · Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins.

热休克蛋白90α是一种细胞质蛋白质，可以作为肿瘤标志物，科学家在1992年发现了这种蛋白。 2016年， 国家食品药品监督管理总局 批准血浆热休克蛋白90α用作肝癌标志物。 Hsp90α是一种细胞质蛋白质，在生物进化过程中高度保守，约占细胞质蛋白的1%～2%。 [1] 肿瘤标志物是由肿瘤细胞合成、释放，或由机体在肿瘤细胞作用下产生的、能够反映肿瘤存在和生长的一类物质。 通常，它在肿瘤患者体内的含量远远超过健康人，在 肿瘤筛查 、诊断、判断预后、评价疗效和高 …

热休克蛋白-90α主要在类肌细胞、间质细胞、支持细胞核及生精细胞的胞浆表达; HSP-90 alpha与肿瘤的关系密切，在许多肿瘤细胞中HSP90α表达升高.