The HSQC (Heteronuclear Single Quantum Coherence) experiment is used to determine proton-carbon single bond correlations, where the protons lie along the observed F2 (X) axis and the carbons are along the F1 (Y) axis. An edited HSQC spectrum of …

The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR.

2023年2月11日 · Hetereonuclear Single Quantum Coherence (HSQC) is used to determine the proton to carbon or heteroatom (often nitrogen) single bond correlations. It is also known as heteronuclear multiple quantum coherence (HMQC).

作者：徐宁 蛋白质相互作用研究的重要性不言而喻，常用的生化研究方法包括GST-pull down、ITC、MST、SPR、BIACORE等方法，这些方法是从分子层面给出蛋白互作的一些结合信息。 复合物高分辨率晶体结构是从原子层面...

Gained Information: The Heteronuclear Single Quantum Correlation (HSQC) NMR experiment is a proton-detected 2D experiment that shows you 1H / 13C one-bond connectivity. You will see your 1H spectrum as your direct F2 axis and your 13C spectrum as your indirect F1 axis.

2015年1月1日 · Proton-detected two-dimensional (2D) NMR experiments, essentially based on two different pulse schemes referred to as heteronuclear single-quantum correlation (HSQC) [1] and heteronuclear multiple-quantum correlation (HMQC) [2], have been key NMR tools during many years for chemists and biochemists to provide valuable structural information on ...

2012年1月1日 · As the title suggests, this chapter focuses on HSQC and HMBC spectra, two critically important spectra for organic structure determination by two-dimensional NMR. The relative merits of the HSQC sequence and the alternative HMQC sequence are discussed, and the performances of different versions of the HSQC sequence are evaluated, using three ...

核磁共振技术（nmr）作为结构鉴定最权威的方法，深受化学家们的衷爱。其中， 1h nmr，13c nmr，dept135°，1h-1h cosy，hsqc和hmbc是实验室最常见的谱图，仅通过氢谱和碳谱，我们通常可以很好地确证简单化合物的结…

HMQC, HSQC, HMBC and COSY are arguably the most useful 2D NMR experiments. HMQC and HSQC give correlation peaks for 1H atoms directly connected (through bond) to heteronuclear atoms and are the standards for determining 1H – 13C one bond correlations.

2004年1月12日 · The basic building blocks of the multitude of double and triple resonance experiments available today are the heteronuclear multiple quantum correlation (HMQC) and heteronuclear single quantum correlation (HSQC) experiments.