2012年1月1日 · SDHD mutations are associated with human cancers but the mechanisms that may contribute to transformation are unknown. The hypothesis that mutations in SDHD increase levels of superoxide leading to genomic instability was tested using site-directed mutagenesis to generate a truncated SDHD cDNA that was expressed in Chinese hamster fibroblasts.

SDHD mutations are associated with human cancers but the mechanisms that may contribute to transformation are unknown. The hypothesis that mutations in SDHD increase levels of superoxide leading to genomic instability was tested using site-directed mutagenesis to generate a truncated SDHD cDNA that was expressed in Chinese hamster fibroblasts.

这些细菌去除7-羟基的能力部分取决于7α-羟基类固醇脱氢酶（HSDH）的活性，该活性可降低其他肠道细菌产生的7-氧代胆汁酸。 3α-HSDH在胆汁酸7α-脱羟基途径中具有重要的酶活性。 据报道，低活性胆汁酸7α-脱羟基细菌梭状芽胞杆菌具有12α-HSDH活性。 但是，对于高活性胆酸7α-脱羟基细菌（如梭状梭状芽胞杆菌，梭状梭状芽胞杆菌，此处，我们证明了这些菌株表达胆汁酸12α-HSDH。 从每种物种鉴定了重组酶，并显示它们优先将12-氧代胆酸还原为脱氧胆酸，对12-氧 …

2024年12月25日 · SDHD (Succinate Dehydrogenase Complex Subunit D) is a Protein Coding gene. Diseases associated with SDHD include Paraganglioma And Gastric Stromal Sarcoma and Pheochromocytoma/Paraganglioma Syndrome 1. Among its related pathways are Citric acid cycle (TCA cycle) and Respiratory electron transport.

副神經節瘤 (PGL)為罕見的腫瘤疾病，30%的PGL病人具有SDH遺傳性基因突變，其中近半數為SDHD異常，臨床症狀主要為好發於頭頸部的良性瘤，但目前腫瘤形成的機制仍未知，利用酵母菌具有和人類基因高度同源的優勢，我們以酵母菌做為動物模式探討PGL的致病機制。

標題: 利用酵母菌系統探討人類SDHD(Sdh4/Shh4)參與遺傳性副神經節瘤之機制 Yeast as a Model to Investigate the Mechanism of hSDHD(Sdh4/Shh4 ...

HSDFinder: an integrated tool for predicting highly similar duplicates (HSDs) in eukaryotic genomes. HSDFinder aims to become a useful platform for the identification and analysis of HSDs in the eukaryotic genomes, which deepen our insights into the gene duplication mechanisms driving the genome adaptation.

2011年10月19日 · SDHD mutations are associated with human cancers but the mechanisms that may contribute to transformation are unknown. The hypothesis that mutations in SDHD increase levels of superoxide leading to genomic instability was tested using site-directed mutagenesis to generate a truncated SDHD cDNA that was expressed in Chinese hamster fibroblasts.

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2012年1月1日 · SDHD mutations are associated with human cancers but the mechanisms that may contribute to transformation are unknown. The hypothesis that mutations in SDHD increase levels of superoxide leading to genomic instability was tested using site-directed mutagenesis to generate a truncated SDHD cDNA that was expressed in Chinese hamster fibroblasts.