The Human Sef-a Isoform Utilizes Different Mechanisms to …
2006年12月22日 · Negative feedback is among the key mechanisms for regulating receptor tyrosine kinase (RTK) signaling. Human Sef, a recently identified inhibitor of RTK signaling, …
Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling
2004年7月1日 · In this study, we report that human Sef (hSef), a recently identified inhibitor whose action mechanism has not been fully defined, acts as a molecular switch for ERK …
hSef Inhibits PC-12 Cell Differentiation by Interfering with Ras ...
2003年12月12日 · Our results demonstrated that stably expressed hSef strongly inhibits FGF2- or nerve growth factor-induced PC-12 cell differentiation. The intracellular domain of hSef is …
Delivery of the gene encoding the tumor suppressor Sef into …
2017年11月8日 · Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is …
Figure - PMC - National Center for Biotechnology Information
(B) Identification of hSef products. HEK 293 cells were transiently transfected with control empty vector (lane 1) or Myc-tagged hSef-b or hSef-a vectors (lanes 2 and 3, respectively). Equal …
Characterisation and in vitro behaviour of hSef ... - ResearchGate
Collectively, hSef properties make it an attractive candidate for cancer gene therapy. ... Delivery of the gene encoding the tumor suppressor Sef into prostate tumors by therapeutic-ultrasound ...
hSef potentiates EGF-mediated MAPK signaling through affecting …
2008年3月1日 · In this report, we found that hSef localizes to the plasma membrane (PM) and is subjected to rapid internalization and well localizes in early/recycling endosomes while poorly …
Similar expression to FGF (Sef) inhibits fibroblast growth factor ...
2009年11月3日 · In a large tissue microarray, we observed a significant loss of hSef protein in high-grade (P <0.0001) and metastatic (P <0.0001) prostate cancer. Considered together, the …
hSef potentiates EGF-mediated MAPK signaling through affecting …
We observed that hSef interacts and functionally colocalizes with EGFR in early endosomes in response to EGF stimulation. Importantly, we demonstrated that overexpression of hSef …
Downregulation of Sef, an inhibitor of receptor tyrosine kinase ...
2007年4月9日 · Here we investigated the expression of Sef, a novel inhibitor of RTK signaling, in normal human epithelial tissues and derived malignancies. Human Sef (hSef) was highly …