2022年5月9日 · The aim was to evaluate p16INK4a and Ki67 expression in normal cervix, LSIL and HSIL and to evaluate the role of p16INK4a and Ki67 in the diagnosis of LSIL and HSIL in biopsy specimens.

We reviewed 2,061 cervical biopsy records, including 271 morphologically indeterminate squamous lesions, evaluated using p16/Ki-67 IHC for HSIL detection or exclusion. HSIL was diagnosed based on p16 positivity and a high Ki-67 labeling index (Ki-LI).

2016年7月18日 · 采用免疫组化双染技术在宫颈上皮细胞或组织中检测两种生物标志物 p16 和 Ki-67 以辅助诊断宫颈癌前病变已成为当前各国研究的重点，通过新检测、新技术的临床应用以实现宫颈癌筛查益处最大化，同时减少和避免由错误诊断和过度诊断带来的不必要的资源浪费 ...

方法 采用免疫组化检测Ki-67、MCM2、p16在宫颈炎症组14例、低级别鳞状上皮内病变（LSIL）组47例、高级别鳞状上皮内病变（HSIL）组49例中的表达情况,以病理结果作为金标准,对结果进行统计分析。

We wish to enhance the existing cervical biopsies of Squamous Intraepithelial Lesions (SIL) using p16 and Ki67 as surrogate markers to assess correlation between its positivity and histological grade of the lesion. Analysis of p16 and Ki67 expression was done on 31 histopathologically diagnosed cases of SILs.

2024年12月18日 · IHC using p16/Ki-67 significantly improved the diagnostic performance for HSIL. In cases that remain inconclusive after IHC, IHC-based risk stratification offers a valuable approach for surveillance, thus mitigating delays in HSIL diagnosis.

2022年5月9日 · The results indicated that Ki67 had high specificity and sensitivity in distinguishing LSIL from normal cervix. p16 was diffusely and strongly positive in some LSILs, and some problems were encountered in the interpretation of p16 staining.

2021年3月17日 · Ki-67免疫组化染色程度可以辅助宫颈组织活检病理为LSIL者进一步分层管理，对于染色程度较重者，要引起高度重视。 美国妇产科医师协会在2016年宫颈癌筛查指南中指出，对HPV感染的焦虑与羞耻是参与宫颈癌筛查女性极为担心的问题，也是临床宫颈癌筛查决策中 ...

目的 比较绝经后妇女子宫颈高级别鳞状上皮内病变 (high-grade squamous intraepithelial lesion,HSIL)与萎缩性改变对p16与Ki-67的免疫组化表达差异,探讨两者的鉴别诊断.方法 选取绝经后妇女诊断为HSIL的病例19例,诊断为萎缩性改变的病例26例,采用免疫组化ELPS法标记p16与Ki-67 ...

本研究表明,P16及Ki-67在宫颈组织中的表达一致性强,呈正相关%两者在宫颈良性病变基本呈阴性表达,在CSIL等级越大,阳性表达率越高%提示P16联合Ki-67检测能有效提高CSIL诊断的敏感度和