HSP90 抑制剂对各种疾病具有治疗作用 HSP90 与癌症 与正常组织相比，癌细胞在 mRNA 和蛋白质水平上表现出更高的 HSP90 表达。 HSP90 抑制剂已被证明可以有效地对抗多种癌症。

HSP90 proteins take part in essential cellular processes and regulatory pathways like apoptosis, cell cycle control, cell viability, protein folding and degradation, and signalling events. In …

Hsp90A is the stress inducible isoform while Hsp90B is expressed constitutively. Several heat shock elements (HSE) are located upstream of Hsp90A allowing for its inducible expression. …

2018年8月29日 · The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular …

Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, …

2023年7月31日 · Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A view...

Hsp90 (Heat Shock Protein 90)是一种在细胞应激条件下诱导表达的分子伴侣蛋白,在发现其可以作为癌症的诊断手段及治疗靶点后,其研究迎来了井喷式的发展。 已有研究表明,Hsp90α不仅与 …

2013年，清华大学罗永章教授首次发现一个全新的肿瘤标志物—— 热休克蛋白90α （HSP90α），并且其自主研发的HSP90α定量检测试剂盒已通过临床试验验证，并获准进入 …

Purpose of review: Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signaling …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell survival, hormone and other signalling …