2024年12月25日 · HSPA12A (Heat Shock Protein Family A (Hsp70) Member 12A) is a Protein Coding gene. Diseases associated with HSPA12A include Leukoencephalopathy With Vanishing White Matter . Among its related pathways are Cellular responses to …

2024年4月8日 · Gain- and loss-of-function studies demonstrated that HSPA12A was required to support cardiomyocyte survival upon hypoxia/reoxygenation (H/R) challenge and that its protective effects were mediated by maintaining aerobic glycolytic homeostasis for H3 lactylation.

2023年8月14日 · Heat shock protein A12A (HSPA12A) shows decreased expression in the brains of schizophrenia patients. However, the causal effects of HSPA12A in any psychiatric disorders are...

2025年2月8日 · Heat-Shock protein A12A is a novel PCNA-binding protein and promotes hepatocellular carcinoma growth. HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma. The genotype "A/G" of rs1665650 in HSPA12A gene was associated with a decreased risk of gastric cancer.

HSPA12A encodes a novel member of the HSP70 family. Here, we report that NASH patients showed increased hepatic HSPA12A expression and serum HSPA12A contents. Intriguingly, knockout of HSPA12A (Hspa12a-/-) in mice attenuated high …

HSPA12A acted as a scaffolding protein to binding both p53 and USP10. USP10 mediated the HSPA12A-increased p53 protein stability. Cardiac fibrosis is the main driver for adverse remodeling and progressive functional decline in nearly all types of heart disease including myocardial infarction (MI).

2024年11月14日 · Heat-shock protein A12A attenuates oxygen-glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell dysfunction via PGC-1α/SIRT3 pathway. HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter interaction.

HSPA12A protects the heart against myocardial ischemia/reperfusion injury by maintaining aerobic glycolytic homeostasis and H3 lactylation in cardiomyocytes by increasing Smurf1-mediated Hif1α protein stabilization.

Targeting HSPA12A in CF could represent a promising strategy for the management of cardiac fibrosis in patients. The present study provided clear evidence that HSPA12A is a novel endogenous inhibitor of CF activation and cardiac fibrosis.

This gene has 30 transcripts (splice variants), 204 orthologues and 4 paralogues. Broad expression in brain (RPKM 23.0), fat (RPKM 11.2) and 16 other tissues. 预测启用 ATP 绑定活动。 位于细胞外外泌体。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable ATP binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]