2024年12月25日 · HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Crohn's Disease and Varicocele . Among its related pathways are Meiosis and Antiviral mechanism by IFN-stimulated genes .

In this review, we summarize the current knowledge on the HSPA2 expression pattern, including information on transcriptional, translational, posttranslational, and epigenetic mechanisms which regulate HSPA2 expression.

Heat shock-related 70 kDa protein 2 is a protein that in humans is encoded by the HSPA2 gene. [5]

2023年3月23日 · 70-kDa Heat Shock Proteins (HSPA/HSP70) are chaperones playing a central role in the proteostasis control mechanisms. Their basal expression can be highly elevated as an adaptive response to...

HSPA2 is a testis-enriched member of the 70 kDa heat shock protein family that promotes the folding, transport, and assembly of protein complexes and has been positively correlated with in vitro fertilization (IVF) success.

This study reinforces the notion that HSPA2 plays a major role in male reproduction orchestrating both spermatogenesis and ultimate expression of sperm function. At a testicular level HSPA2 has been shown to play an essential role in the transition of mouse spermatogenic cells through the late meiotic stages of spermatogenesis , .

HSPA2 may play an important role in tumor progression, and serve as a potential biomarker for the prediction of adverse prognosis in pancreatic carcinoma; HSPA2 appears to be necessary for controlling development of properly stratified epidermis and …

2020年9月24日 · Heat Shock Protein A2 (HSPA2) is a member of the HSPA (HSP70) chaperone family and has a critical role for male fertility. HSPA2 is present in a number of somatic organs. Limited evidence suggests that HSPA2 may be involved in regulating epithelial cell differentiation.

HSPA2 is a testis-enriched member of the 70 kDa heat shock protein family that promotes the folding, transport, and assembly of protein complexes and has been positively correlated with in vitro fertilization (IVF) success.

In this chapter, we consider the unique structural and biochemical characteristics of HSPA2 that enable this heat shock protein to fulfil its prominent roles in orchestrating the morphological differentiation of male germ cells during spermatogenesis as well as their functional transformation during post-testicular sperm maturation.