Headspace sampling is a type of sample introduction technique for gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS). For headspace techniques, the gas layer, or the headspace above the sample in a vial, is analyzed as opposed to withdrawing a volume from within the sample layer (Figure 1).

Headspace gas chromatography uses headspace gas—from the top or "head" of a sealed container containing a liquid or solid brought to equilibrium [1] —injected directly onto a gas chromatographic column for separation and analysis. In this process, only the most volatile (most readily existing as a vapor) substances make it to the column. [2] .

Headspace GC is a sample preparation method for determining volatile compounds in solid and liquid samples. The technique has existed since the late 1950s [12] and is still actively used. With this technique, only the gas phase above the sample is introduced into the GC column.

2014年6月2日 · This review surveys headspace gas chromatographic (HS-GC) methods as used in the determination of volatile substances in body fluids and tissues from the viewpoints of the design of HS-GC ...

2020年7月30日 · Ideal for analysis of volatile analytes in matrices that can’t be directly injected into the GC. Static vs. dynamic Dynamic – A continuous gas stream is passed through a sample that then elutes the compounds of interest onto a trap, where they are held and concentrated.

2021年1月1日 · The term “headspace” in gas chromatography (GC) denotes the vapor phase within a sealed container also containing a liquid or solid. Usually, the vapor is above the liquid or solid, at the top of the container, hence the term “headspace.”

2002年9月10日 · Recent developments and trends in the use of headspace sampling with gas chromatography (GC) are reviewed and discussed. A brief overview of headspace analysis techniques and theory references is provided, followed by publication trend data on the various headspace-analysis techniques.

2016年2月29日 · Question: Why would headspace GC be a good sampling technique? Answer: Headspace sampling is excellent for the qualitative or quantitative analysis of volatile species in samples that can be efficiently partitioned into the headspace gas volume from either a liquid or solid matrix. It is also a good technique for the analysis of samples where ...

Headspace is used to analyze volatile compounds in liquid and solid samples that cannot be injected directly into a gas chromatograph (GC). Examples would be creams and lotions, blood, soil, electronic components, and polymers. Headspace sampling can accommodate virtually any matrix. How does headspace sampling work?

After a brief overview of the techniques of static and dynamic headspace sampling and examples are given for the dynamic method (“purge and trap”). With respect to static headspace—gas chromatography (HS-GC) the theoretical background of the technique and the principles of the existing instruments are outlined.