When the 5-HT 7 receptor is activated by serotonin, it sets off a cascade of events starting with release of the stimulatory G protein G s from the GPCR complex. G s in turn activates adenylate cyclase which increases intracellular levels of the second messenger cAMP.

2024年12月25日 · HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include Migraine With Or Without Aura 1 and Alcohol Dependence. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs.

HTR7 is a susceptibility gene for schizophrenia in this Japanese group. The decrease in affinity of 5-HT and other 5-HT receptor agonists at the (Thr92Lys) h5-HT7 receptor may be associated with changes of sleep physiology and of actions of new 5-HT7 receptor agonists designed to treat circadian dysregulation.

2025年1月4日 · HTR7 is a direct target of miRNA-29a. MiRNA-29a plays a role in visceral hyperalgesia pathogenesis of IBS. Title: MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7.

2020年7月20日 · In the present study, we used a combination of genetic, pharmacological and high-resolution imaging approaches to evaluate the developmental role of 5-HTR7 in the synaptic wiring of the...

Previous animal studies have shown that knockout of the serotonin receptor 7 gene (HTR7) resulted in an antidepressant-like phenotype, suggesting it was important to antidepressant action.

HTR7 (HGNC Symbol) Synonyms: 5-HT7: Description: 5-hydroxytryptamine receptor 7 (HGNC Symbol) Entrez gene summary: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions.

We aggregated Htr1 and Htr5 due to their inhibitory effect (cAMP decrease) and Htr4, Htr6, and Htr7 because of the shared downstream effect of increasing cAMP. Htr2 is the only one that causes a Ca 2+ increase, while Htr3 is the only ionotropic receptor.

2024年9月27日 · Our research revealed the ability of Htr7 + Tregs to mitigate neuroinflammation and prevent neuronal damage by suppressing the infiltration of CD8 + T cells into the brain and excessive activation of microglia, thereby ameliorating LPS-induced cognitive impairment.

We found that HTR7 is expressed in a subset of primary afferent sensory neurons that innervate the skin and promote acute itch but not pain behaviors. HTR7 is functionally coupled to the irritant receptor TRPA1, and together they trigger neuronal excitation and mediate acute serotonergic- and SSRI-evoked itch.