Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in
2009年12月11日 · Hydroxyurea (HU) specifically inhibits class I ribonucleotide reductase (RNR), depleting dNTP pools and leading to replication fork arrest. Although HU inhibition of RNR is …
The Cell Killing Mechanisms of Hydroxyurea - PMC
HU inhibits its primary cellular target ribonucleotide reductase (RNR), which decreases the deoxyribonucleotide triphosphate (dNTP) levels and slows the movement of DNA polymerases …
Hydroxyurea—The Good, the Bad and the Ugly - PMC - PubMed …
Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR) and as the agent that is commonly used to arrest cells in the S-phase of the cycle by inducing …
Hydroxyurea Induces a Stress Response That Alters DNA …
Hydroxyurea (HU) is classified as a ribonucleotide reductase (RNR) inhibitor and has been widely used to stall DNA replication by depleting deoxyribonucleoside triphosphate (dNTP) pools. …
Genome-Wide Screening with Hydroxyurea Reveals a Link …
2013年2月22日 · We performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli. HU inhibits ribonucleotide reductase …
Revised Mechanism of Hydroxyurea Induced Cell Cycle Arrest and …
2024年3月2日 · The primary mechanism of S-phase checkpoint activation by HU has thus far been considered to be a reduction of dNTP synthesis by inhibition of ribonucleotide reductase …
The in Vivo Toxicity of Hydroxyurea Depends on Its Direct Target ...
2010年7月7日 · Although RNR properties influence HU resistance in cell lines, the mechanisms underlying cancer HU resistance in vivo remain unclear. To address this issue, we screened …
Hydroxyurea Induces a Stress Response That Alters DNA
2021年7月8日 · Hydroxyurea (HU) is classified as a ribonucleotide reductase (RNR) inhibitor and has been widely used to stall DNA replication by depleting deoxyribonucleoside triphosphate …
dNTP deficiency induced by HU via inhibiting ribonucleotide …
2015年2月3日 · The present study aimed to examine the effects of dNTP deficiency induced by hydroxyurea (HU), a specific ribonucleotide reductase (RNR) inhibitor, during murine neural …
A ribonucleotide reductase inhibitor with deoxyribonucleoside ...
Ribonucleotide Reductase (RNR) is the sole enzyme that catalyzes the reduction of ribonucleotides into deoxyribonucleotides. Even though RNR is a recognized target for …