2022年4月13日 · The in vivo map of human HSC ontogeny validated the generation of aorta–gonad–mesonephros-like definitive haematopoietic stem and progenitor cells from human pluripotent stem cells, and serves...

2025年3月7日 · The most immature subpopulations HSC-1 and HSC-2 were characterized by high expression of CD34 and CD90 and the absence of early differentiation antigens, CD38 and CD45RA (Fig. 4a, Supplementary ...

造血干细胞 （hematopoietic stem cell， HSC）能够在体内产生所有类型的血液细胞，并且通过自我更新和多系分化维持个体整个生命周期的血液系统功能。 虽然HSC的发生过程在斑马鱼和小鼠等动物模型已经被充分揭示，但受限于研究技术的缺乏和研究材料的稀缺，目前对人类早期胚胎造血发育的认识仍十分有限。 研究人员通过异种移植的功能分析，确认了人类的HSC于胚胎卡内基阶段（Carnegie stage，CS）14（妊娠后32天）最早出现在主动脉-性腺-中 …

2023年4月18日 · Here, we present a convenient strategy for human HSC expansion based on a biomimetic Microniche. After demonstrating the expansion of HSC from different sources, we find that our...

2022年11月22日 · Hematopoietic stem cells can be functionally classified as either long-term HSCs (LT-HSCs) or short-term HSCs (ST-HSCs). LT-HSCs are self-renewing cells that exist in a predominantly quiescent/dormant state, while ST-HSCs (also known as progenitor cells) are ready to differentiate but can also return to dormancy.

HSCs are functionally defined by their ability to stably reconstitute the entire blood and immune systems following transplantation. HSCs can be prospectively isolated using fluorescence activated cell sorting (FACS) based on surface marker expression.

The single cell Atlas of Human Hematopoietic Stem Cell Development provides access to gene expression profiles of human HSCs throughout ontogeny. This Atlas covers developing human HSCs from their specification and emergence from hemogenic endothelium throughout their migration and maturation in the different hematopoietic niches.

2022年4月17日 · 该研究以： Mapping human haematopoietic stem cells from haemogenic endothelium to birth 为题发表在国际顶尖学术期刊 Nature 上。 通过创建人类造血发生的单细胞转录组图谱，他们 记录了 HSC 从动脉造血内皮细胞产生的全过程，并使用空间转录组学可视化主动脉内造血群（Intra-Aortic Haematopoietic Clusters, IAHCs）中 HSC 的产生。 此外， 通过比较不同成熟阶段的 HSC，建立了 HSC 出现后的转录因子机制，揭示了其表面分子标志物在整个发 …

Human hematopoietic stem cells (HSCs) are tissue-specific adult stem cells capable of differentiating into all blood cell types to ensure the homeostasis of blood throughout life.

2023年8月10日 · Human hematopoiesis starts by 2.5 weeks (CS7) in the yolk sac, with the first, primitive progenitor wave, during which the main products are nucleated primitive erythroblasts that enter circulation.