2018年12月20日 · The maternal-to-zygotic transition (MZT) is the process by which the transcriptionally silent embryonic genome is gradually activated.

2020年10月1日 · In this study, we define and characterize the ZGA-dependent maternal mRNA clearance process during human MZT and demonstrate that subgroups of the human maternal transcripts are sequentially ...

Maternal-to-zygotic transition (MZT) refers to an initial step in the early embryonic development, consisting of two strictly coordinated phenomena, i.e., zygotic genome activation (ZGA) and the degradation of maternal gene transcripts.

2024年11月25日 · During this maternal-to-zygotic transition (MZT), which is conserved in metazoans, transient totipotency is induced and zygotic transcription is initiated to form the blueprint for future...

Maternal to zygotic transition (MZT), also known as embryonic genome activation, is the stage in embryonic development during which development comes under the exclusive control of the zygotic genome rather than the maternal (egg) genome. The egg contains stored maternal genetic material mRNA which controls embryo development until the onset of ...

2025年2月10日 · The mechanism and key regulators of maternal-to-zygotic transition (MZT) remain largely unknown in human embryo development. By single-nucleotide polymorphism (SNP) allele genotype analysis of parental genome, we could determine the parent-of-origin of embryonic transcripts after single-cell RNA sequencing, further reveal key regulators during MZT.

2025年1月13日 · Our study identifies the factors of MZT and lineage specification, DPRX and ARGFX, in human embryos, and further validates that their deficiency directly contributes to human cleavage-stage arrest. However, due to the scarcity of human embryos, it is an enormous challenge to further explore their regulatory mechanisms directly in human embryos ...

2025年1月9日 · Here, by performing allelic transcriptome analysis on human preimplantation embryos, we accurately quantified MZT progression by allelic ratio and identified a fraction of 8-cell embryos, at the appropriate developmental time point and exhibiting normal morphology, were in transcriptionally arrested status.

Here we report the zygotic genome activation (ZGA)-dependent and -independent maternal mRNA clearance processes during human MZT and demonstrate that subgroups of human maternal transcripts are sequentially removed by maternal (M)- and zygotic (Z)-decay pathways before and after ZGA.

2022年8月2日 · Maternal-to-zygotic transition (MZT) refers to an initial step in the early embryonic development, consisting of two strictly coordinated phenomena, i.e., zygotic genome activation (ZGA) and the degradation of maternal gene transcripts.