Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during …

2022年6月20日 · The sodium taurocholate (TC) co-transporting polypeptide NTCP (SLC10A1) is a secondary active membrane transport protein that mediates the uptake of bile salts from the …

NTCP (sodium taurocholate cotransporting polypeptide)指钠离子-牛磺胆酸共转运蛋白，通常在人肝细胞表面表达。 该受体又称牛磺胆酸钠共转运蛋白。 因发现该受体，北京生命科学研究所 …

2022年5月17日 · Our preS1 domain interaction analysis enables a mechanistic interpretation of naturally occurring HBV-insusceptible mutations in human NTCP. Together, our findings …

Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as …

2022年9月13日 · Revealing NTCP structure is a great leap toward unlocking the mysteries of NTCP and opening a new era of manipulating NTCP to encourage structure-based anti-HBV …

Revealing NTCP structure is a great leap toward unlocking the mysteries of NTCP and opening a new era of manipulating NTCP to encourage structure-based anti-HBV drug development or to …

2022年5月11日 · Human Na + –taurocholate co-transporting polypeptide (NTCP) is the main bile salt uptake system in liver. NTCP is also the cellular entry receptor of human...

recently revealed the cryoelectron microscopy (cryo-EM) structure of the human NTCP, providing detailed views of NTCP under different states and conditions (Figure 1). Goutam et al.2 …

2024年9月1日 · Researchers developed a potent and high-affinity human NTCP-targeted compound, DBA-41, and investigated its effects in human NTCP knock-in mice; the results …