2021年6月9日 · In the present study, we show that a subset of human T H 17 cells engages an NLRP3-dependent signaling cascade to induce membrane pore formation by GSDME, which …

Orchestra of cytokines regulates phenotypic and functional plasticity of non‐pathogenic and pathogenic Th17 cells in human health and diseases. Keywords: Cytokine modulation, Human …

Recent data in humans and mice suggest that Th17 cells play an important role in the pathogenesis of a diverse group of immune-mediated diseases, including psoriasis, …

2023年11月30日 · By combining PIM triple knockdown with bulk and scRNA-seq approaches, we found that PIM deficiency promotes the early expression of key Th17-related genes while …

Initial studies in humans have confirmed the existence of Th17 cells, but they have shown that the origin of these cells in humans differs from that in mice, with IL-1β and IL-23 being the major …

2021年5月21日 · Herein, by performing transcriptome analysis of human Th17 cells, we uncovered three time-regulated modules: early, involving exclusively “signaling pathways” …

2011年10月12日 · Human TH17 cells phenotypically resembled terminally differentiated memory T cells but were distinct from central memory, exhausted, and senescent T cells. Despite their …

The T helper 17 (Th17) cell pathway has been linked by genome-wide association studies to multiple autoimmune diseases. Identification of the genetic causes of primary …

2021年6月1日 · Cumulating research has demonstrated the critical roles of Th17 in autoimmune diseases and cancer, suggesting that Th17 is an ideal target for the treatment of many human …

Th17 cells are a lineage of CD4 + T helper cells with Th17-specific transcription factors RORγt and RoRα. Since its discovery in 2005, research on Th17 has been in rapid progress, and …