自 1995 年首次描述，调节性 T 细胞 （Treg） 领域迅速扩大，已发现 Treg 在各种环境中发挥着关键作用，包括自身免疫性疾病、癌症和移植。 为了更好地了解 Treg 介导的作用，已经开发了多种 Treg 相关试验， Treg已成为研究生物学和开发新治疗策略的重要工具。

2021年5月11日 · Our data demonstrate that human inflammation-derived Treg cells acquire a conserved and specific eTreg cell profile guided by epigenetic changes, and fine-tuned by environment-specific...

2025年2月3日 · Single-cell suppression profiling of human Tregs (scSPOT) is based on altering the number of Tregs present in total PBMCs and assay by a 52-marker CyTOF panel combining recent...

2019年2月19日 · Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell activation and differentiation states in different human pathologies.

2018年1月11日 · Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived Tregs. Unlike highly suppressive but plastic memory Tregs...

2024年5月30日 · Regulatory T cells (Tregs) are essential to maintain immune homeostasis by promoting self-tolerance. Reduced Treg numbers or functionality can lead to a loss of tolerance, increasing the risk of developing autoimmune diseases. An overwhelming variety of human Tregs has been described, based on eithe …

2025年3月18日 · Taken together, a significant proportion of studies have addressed the basic biology of human Tregs in age but do not address the complex interactions of Treg with other immune cells within an aged immune system. Given the significant caveats associated with functional Treg suppressor assays, one avenue to discern Treg function would be to ...

2018年1月30日 · FOXP 3‐expressing CD 4 + T regulatory (Treg) cells are instrumental for the maintenance of self‐tolerance. They are also involved in the prevention of allergy, allograft rejection, foetal rejection during pregnancy and of exaggerated immune response towards commensal pathogens in mucosal tissues.

2025年3月5日 · Regulatory T cells (Tregs), a rare subset of immune cells tasked with maintaining immune homeostasis, have emerged as a promising cellular therapy for autoimmune disease, graft-versus-host disease, and organ transplant rejection. 1 Early clinical trials using polyclonal Tregs have demonstrated safety and tolerability.

1 天前 · Regulatory T (Treg) cells modulate immune responses and attenuate inflammation. Extracellular vesicles from human cardiosphere-derived cells (CDC-EVs) enhance Treg proliferation and IL10 production, but the mechanisms remain unclear. Here we focus on BCYRN1, a long noncoding RNA (lncRNA) highly abundant …