2023年3月28日 · Hydralazine is a direct vasodilator used orally to treat essential hypertension, among other diseases, and intravenously to rapidly reduce blood pressure in hypertensive urgency or emergency. Per JNC 8 guidelines, it is not a first-line agent for the treatment of essential hypertension.

Hydralazine is a direct-acting smooth muscle relaxant and acts as a vasodilator primarily in resistance arterioles, also known as the smooth muscle of the arterial bed.

Pharmacodynamics. Hydralazine interferes with calcium transport to relax arteriolar smooth muscle and lower blood pressure. 19 Hydralazine has a short duration of action of 2-6h. 10 This drug has a wide therapeutic window, as patients can tolerate doses of up to 300mg. 19 Patients should be cautioned regarding the risk of developing systemic lupus erythematosus syndrome. 19

2020年2月17日 · Based on the American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guidelines for the management of heart failure, hydralazine (in combination with isosorbide dinitrate) is effective and recommended as additional therapy to optimal guideline-directed medical therapy for self-identified African-American patients with per...

2004年6月10日 · We present evidence that hydralazine rapidly and transiently induces HIF-1α protein and downstream targets of HIF via inhibition of the PHD enzymes and stimulates specific endothelial cell (EC) proliferation in culture and rapid neo-angiogenesis in vivo.

Hydralazine is a direct vasodilator used orally to treat essential hypertension, among other diseases, and intravenously to rapidly reduce blood pressure in hypertensive urgency or emergency. Per JNC 8 guidelines, it is not a first-line agent for the treatment of …

2011年5月31日 · They found that H-ISDN reduced left ventricular filling pressure by 36%, increased cardiac index by 58%, and reduced systemic vascular resistance by 34%. Later, Pierpont et al 14 compared H-ISDN with nitroprusside and showed that the 2 therapies had similar effects on wedge pressure reduction and cardiac index increase.

We present evidence that hydralazine rapidly and transiently induces HIF-1 protein and downstream targets of HIF via inhibition of the PHD enzymes and stimulates specific endothelial cell (EC) proliferation in culture and rapid neo-angiogenesis in vivo.

2023年8月4日 · Hydralazine is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Hydralazine is …

New York Heart Associated Class III or IV HF with reduced ejection fraction (in combination with isosorbide dinitrate). Direct-acting peripheral arteriolar vasodilator. Lowering of BP in hypertensive patients and decreased afterload in patients with HF. Absorption: Rapidly absorbed following oral administration; well absorbed from IM sites.