This combination medication is used to relieve moderate to severe pain. It contains an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a …

2024年11月8日 · Find patient medical information for Hydrocodone/Acetaminophen (Norco, Vicodin, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings...

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Hydrocodone 10 mg is equivalent to about 10 mg of morphine by mouth. [16] Hydrocodone was patented in 1923, while the long-acting formulation was approved for medical use in the United States in 2013. [10][17] It is most commonly prescribed in the United States, which consumed 99% of the worldwide supply as of 2010. [18] .

Hydrocodone produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation. Hydrocodone causes miosis, even in total darkness.

2015年1月15日 · Hydrocodone bitartrate is an opioid analgesic and antitussive and occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical name is 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5).

2023年8月16日 · Dose adjustments to hydrocodone extended-release tablets should be made in 10 to 20 mg increments every 24 hours, every 3 to 5 days. If unacceptable side effects occur, the dose may be reduced. Breakthrough Pain: If the level of pain increases after dose stabilization, attempt to identify the source before increasing dose; rescue medication ...

Initial dose: hydrocodone 0.135 mg/kg and acetaminophen 4 or 5.85 mg/kg orally every 4 to 6 hours as needed. For hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL Oral Solution: 0.27 mL/kg orally every 4 to 6 hours; For hydrocodone 10 mg-acetaminophen 300 mg per 15 mL Oral Solution: 0.2 mL/kg orally every 4 to 6 hours; Maximum: 6 doses in 24 hours