2018年11月13日 · Hypergammaglobulinemia is an uncommon condition that is usually the result of an infection, autoimmune disorder, or malignancy such as multiple myeloma. It’s characterized by elevated...

2023年7月31日 · Hypergammaglobulinemia (polyclonal gammopathy) refers to the overproduction of more than one class of immunoglobulins by plasma cells. It is most commonly associated with liver disease, acute or chronic inflammation, autoimmune disorders, and some malignancies.

Polyclonal gammopathy, also known as hypergammaglobulinemia, is a condition in which white blood cells make too many proteins (antibodies). Healthcare providers treat the underlying cause of the immune response to help treat polyclonal gammopathy. What is polyclonal gammopathy?

Hypergammaglobulinemia is a condition that is characterized by the increased levels of a certain immunoglobulin in the blood serum. [1] . The name of the disorder refers to an excess of proteins after serum protein electrophoresis (found in the gammaglobulin region). [citation needed]

Hypergammaglobulinemia can stem from various causes, often linked to chronic infections, autoimmune diseases, or malignancies. Understanding the underlying causes is essential for effective diagnosis and treatment. Chronic infections such as hepatitis, tuberculosis, and HIV are common culprits.

2016年10月1日 · Polyclonal hypergammaglobulinemia (PHGG) has historically been associated with a variety of conditions including liver disease, 1 infections such as that by human immunodeficiency virus, 2 hematologic disorders such as idiopathic neutropenia, 3 nonhematologic malignancies, and autoimmune conditions such as Sjögren syndrome. 4 To …

2017年6月23日 · Hypergammaglobulinemia is an immune disorder that is actually a fairly rare occurrence. Essentially, it is when your immune system malfunctions and there is a deficiency in B-cells (B-lymphocytes), which leads it to increase the amount of gamma globulins (a type of antibody) in your bloodstream.

Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also provide an important diagnostic clue of rare diseases such as histiocyte disorders, autoimmune lymphoproliferative syndrome, Castleman disease, and IgG4-related disease.

Polyclonal hypergammaglobulinaemia: assessment, clinical interpretation, and management. Lancet Haematol 2021; 8: e365-75. Cowan AJ et al. Diagnosis and management of multiple myeloma: a review. JAMA 2022; 327: 464-77.

increased gamma globulins in the blood. adj., adj hypergammaglobuline´mic. monoclonal h's an excess of homogeneous immunoglobulin molecules of a single specificity in the blood following proliferation of a clone of immunoglobulin-producing cells.