Interstate 81 (I-81) is a north–south (physically northeast–southwest) Interstate Highway in the eastern part of the United States.

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The I-81 Interstate 81 Highway is a major automotive & trucking transportation corridor and interstate highway that travels generally in a north/northeast-south/southwest direction along the eastern inland coast of the USA.

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Interstate 81 does not enter major metropolitan areas; it instead serves an array of small to mid-size cities. The route commences from a rural directional T interchange near Dandridge, Tennessee to run northeast across agricultural areas and forest land along the west side of the Appalachian Mountains to the Tri-Cities region.

Traffic not moving. Been here two hours Open Report. 2 + 2 = ?

81號州際公路 （Interstate 81，簡稱 I-81）是 美國 州際公路系統 的一部份。 北接 加拿大 安大略401省道，南至 田納西州 丹德里治 （Dandridge）。 全長854.89英里（1375.81公里）。 與 美國國道11 大致平行。 沿 阿帕拉契山脈 而行，由於相對起 95號州際公路 比較遠離城市，成為 貨車 行走 美國東岸 的主要通道。 ^ 1.0 1.1 Route Log and Finder List - Interstate System: Table 1. 美國聯邦公路管理局. [2007-10-02]. （原始内容 存档 于2007-07-02）.

81号州际公路 （Interstate 81，简称 I-81）是 美国 州际公路系统 的一部份。 北接 加拿大 安大略401省道，南至 田纳西州 丹德里治 （Dandridge）。 全长854.89英里（1375.81公里）。 与 美国国道11 大致平行。 沿 阿帕拉契山脉 而行，由于相对起 95号州际公路 比较远离城市，成为 货车 行走 美国东岸 的主要通道。 ^ 1.0 1.1 Route Log and Finder List - Interstate System: Table 1. 美国联邦公路管理局. [2007-10-02]. （原始内容 存档 于2007-07-02）.

Interstate 81 enters the state of New York near Binghamton. It follows U.S. Route 11 in a north–south direction, through much of the state. It serves the cities of Syracuse (where it intersects the New York State Thruway), and Watertown.

Interstate 81 (abbreviated I-81) is an interstate highway in the eastern part of the United States. Its southern terminus is at Interstate 40 near Dandridge, Tennessee; its northern terminus is on Wellesley Island (near Fishers Landing, New York) at the Canadian border, where the Thousand Islands Bridge connects it to Highway 401, the main ...