三苯基膦、咪唑、碘体系进行碘代反应，三者一般1eq-1.5eq。 溶剂用的有：二氯甲烷，甲苯，四氢呋喃，乙腈和乙醚，反应的时候最好避避光，反应要求无水。 通常情况下反应温度低，反应时间短，产率高，另外有些底物是需要加热才能反应。 To dry dichloromethane (4 mL) was added in order: triphenylphosphine (1.2~1.5 mmol), imidazole (1.2~1.5 mmol) and iodine (1.2~1.5mmol).

The Appel reaction is an organic reaction that converts an alcohol into an alkyl chloride using triphenylphosphine and carbon tetrachloride. [1] . The use of carbon tetrabromide or bromine as a halide source will yield alkyl bromides, whereas using carbon tetraiodide, methyl iodide or iodine gives alkyl iodides.

2013年9月9日 · An efficient and stereoselective spiroannulation of unsaturated enols is reported. Unsaturated β-dicarbonyl compounds undergo cyclization by reaction with catalytic I2–PPh3, affording the corresponding spiro enol ether derivatives, with complete regio- and stereoselectivity, under mild conditions. Utilizing

2023年9月1日 · A simple and efficient method for the synthesis of unsymmetrical disulfides is reported. Using sodium sulfites and 2-mercaptobenzo heterocyclic compounds as starting materials, the unsymmetrical sulfur–sulfur bonds could be quickly constructed in the PPh 3 /I 2 reaction system under transition–metal-free conditions.

2005年5月23日 · In view of the parallelism observed in the behaviour of tertiary alcohols and their acetyl derivatives against the PPh 3 –I 2 system, 11 tertiary allyl acetates were also investigated. Compounds 1b–5b, having the same stereochemistry as …

2023年10月30日 · An I2/PPh3-mediated synthesis of 3-thiolated chromones starting from 2-hydroxyphenylenones and sodium sulfinates was reported. This method features one pot manner, metal-free, easy performance, readily available starting materials and illustrating potential value for some biologically or pharmaceutically active compounds.

2019年3月1日 · During the course of our studies, we found PPh 3 /I 2 /HCOOH could release CO efficiently and rapidly (Scheme 1). This result inspired us that PPh 3 /I 2 /HCOOH might be as CO precursor used in organic synthesis.

2023年10月30日 · An I 2 /PPh 3 -mediated synthesis of 3-thiolated chromones starting from 2-hydroxyphenylenones and sodium sulfinates was reported. This method features one pot manner, metal-free, easy performance, readily available starting materials and illustrating potential value for some biologically or pharmaceutically active compounds.

碘（i2）是一种亲核试剂，具有强氧化性。 在反应中，碘会发生电子求取，与PPh3形成碘化三苯基膦。 此外，碘还能通过碘化亚铜（CuI）催化生成碘化三苯基膦。

2013年9月24日 · Unsaturated β-dicarbonyl compounds undergo cyclization by reaction with catalytic I2-PPh3, affording the corresponding spiro enol ether derivatives, with complete regio- and stereoselectivity ...