2022年7月1日 · Intestinal fatty acid binding protein, also termed FABP2 or I-FABP, is specifically expressed in the small intestine. FABP2 can traffic lipids from the intestinal lumen to enterocytes and bind superfluous fatty acids to maintain a steady pool of fatty acids in the epithelium.

Among the FABP family proteins, intestinal fatty acid-binding protein (I-FABP) is specifically and abundantly present in epithelial cells of the mucosal layer of the small intestinal tissue. I-FABP is also considered to be rapidly released into the circulation …

肠脂肪酸结合蛋白，也称为 FABP2 或 I-FABP，在小肠中特异性表达。 FABP2 可以将脂质从肠腔运输到肠细胞并结合多余的脂肪酸以维持上皮细胞中稳定的脂肪酸库。 作为脂质伴侣，FABP2还可以携带亲脂性药物以促进靶向转运。 当肠上皮的完整性被破坏时，FABP2 被释放到循环中。 因此，它可以潜在地用作临床生物标志物。 在本次审查中，我们讨论了 FABP2 在肠道脂质代谢中的关键作用。 我们还总结了迄今为止报告的分子相互作用，突出了 FABP2 研究的临床前景。 脂 …

2019年9月16日 · I-FABP is the most studied of the three as regards human GI disease because of its specificity to the small intestine. Moreover, I-FABP levels can be detected at low levels in blood consequent to the constant shedding of mature enterocytes from …

i-FABP特异性表达于小肠黏膜细胞，其在正常情况下不能在外周血中检测到，研究发现肠屏障功能障碍发生早期其血浆水平就会显著升高。 1 代谢特点及检测方法1.1 D-乳酸D-乳酸是肠道细菌发酵产生的代谢产物，其在肠黏膜通透性增加时即可进入血液循环，当外周血检测到D-乳酸时说明该患者肠道受到细菌感染且通透性增加，该标记物可作为特异性较好的预警指标 [1] 。 D-乳酸的检测可根据Murray方法用邻-二甲氧基苯胺进行 [2] ，也可通过酶联免疫吸附试验试剂盒 (R&D …

2024年1月1日 · Th17 cells promote tissue inflammation, and Treg cells suppress autoimmunity in IBD. Therefore, Th17/Treg cell balance is crucial. We found that FABP5-IN-1 could regulate Th17/Treg differentiation, thus regulating Th17/Treg cells and exerting an anti-inflammatory effect in IBD animal models.

2024年11月11日 · 研究通过观察IBD患儿血清I-FABP、IL-1β及FC水平表达，分析其与疾病活动度的相关性，为IBD的诊断及病情评估提供依据。 （一）研究对象： 选取140例IBD患儿为IBD组，其中57例CD患儿为CD组，83例 UC 患儿为 UC 组，另选同期35例肠易激综合征（IBS）患儿为 IBS 组。 CD组男31例，女26例，年龄2-11岁，平均 (6.25±1.06)岁；UC组男43例，女40例，年龄2-12岁，平均 (6.11±1.14)岁；IBS组男18例，女17例，年龄1-14岁，平均 (5.97±1.21)岁。 三组 …

Intestinal fatty acid-binding protein (I-FABP) has been identified as a marker for intestinal damage and correlates with the degree of inflammation. The aim of the present study was to evaluate whether I-FABP can predict active disease or remission in Crohn's disease (CD) and ulcerative colitis (UC) in a real-life IBD cohort.

Intestinal fatty acid- binding proteins (I-FABP) defined as circulating or urinary markers of intestinal epithelial damage in patients with acute ischemia of the small bowel. Aim and objectives: to evaluate I-FABP level in the follow up of treated IBD patients compared to …

2016年4月30日 · Intestinal fatty-acid binding protein (I-FABP) is expressed in epithelial cells of the mucosal layer of the small intestine tissue. When intestinal mucosal damage occurs, I-FABP is released into the circulation and its plasma concentration increases.