IBD mouse models remain a crucial tool for preclinical research and drug development; each model undoubtedly has specific advantages/limitations over other models, such as the CD45RB model which provided useful information to understand the adaptive immune system mechanisms associated with the pathogenesis of IBD.

炎症性肠病（IBD）是一种特发性肠道炎症性疾病，主要累及回肠、直肠和结肠。 其临床表现为腹泻、腹痛，甚至可能出现血便。 IBD包括两种亚型： 溃疡性结肠炎 （UC）和克罗恩病（CD）。 IBD发病机制十分复杂，涉及遗传、免疫反应、环境因素以及肠道感染等多个方面。 目前，全球超过1000万人患有IBD，而在我国，IBD发病率也已超过3/100,000 [2]。 然而，IBD的诊断过程复杂，且目前尚无治愈方法。 随着疾病护理成本的不断增加，人们迫切需要采取有效策略来减轻 …

Nov 21, 2024 · Herein, we developed novel complex IBD models using interleukin 2 receptor subunit gamma (Il2rg)-deficient mice, high-fat diet, dextran sodium sulfate, and Citrobacter rodentium. The more IBD factors applied complexly, colon length shortened and inflammation worsened. The levels of pro-inflammatory cytokines increased with increased IBD factors.

Mar 18, 2016 · Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of the disease, identifying new targets for therapeutic intervention, and testing novel therapeutics. This unit provides detailed protocols for five widely used mous …

该亚品系为IBD发病的免疫机理研究提供了十分有价值的模型，揭示出B和T细胞的对肠道细菌菌群抗原的反应性增强，以及对特定细菌抗原的血清IgG抗体水平升高。 自发性IBD模型的一个主要局限是疾病完全显现所需的时间长。 例如，对于SAMP1/Yit品系，100％的外显率大约需要30周。 这可能会导致较长科研时间、且昂贵费用。 过继性T细胞移植模型会引起小肠和结肠慢性炎症，这与人类IBD的一些关键方面非常相似。 从供体BALB/c脾细胞中分离获得CD4+CD45RBhi T细 …

Jul 27, 2021 · Animal models provide valuable platforms for studying IBD heterogeneity and deciphering disease-specific mechanisms. Both the established and the newly developed ileitis mouse models are...

Jun 1, 2017 · Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further potential complications such as tissue fibrosis and stenosis. Animal models help in understanding the...

Apr 16, 2024 · Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability.

Improve the translation of your inflammatory bowel disease research with IBD mouse models and relevant cellular assays from Charles River. Our experts can guide your selection of the appropriate models depending on your therapeutic target, resulting in data that accurately represents human IBD.

Apr 4, 2025 · Leverage our chemically induced murine model of Inflammatory Bowel Disease to accelerate your research on IBD and explore potential therapeutic interventions. ... C57BL/6 female mice were used in this study, which divided the animals into three groups: one group received normal water, another received a 3.5% concentration of Dextran Sodium ...