2022年9月28日 · The changes in CRT, HMGB1, HSP70, and ATP levels after BSA-FITC-Man@Mn 2+-Ft@Lap treatment are immediate evidence for the ICD-inducing ability of the nanoassembly on 4T1 tumor cells, which...

为研究 dox 作为乳腺癌 4t1 肿瘤模型中 icd 诱导剂功效，作者监测 icd 生物标志物（ atp/crt ）和 ido1 表达的水平，随 dox 浓度升高， atp 、 crt 水平逐渐增加，但 cis 对照组处理下二者水平并未增加（图 1a-d ）；用 4t1 细胞进行疫苗接种实验并评估肿瘤大小， dox 处理 ...

These results suggested that the either chemotherapy or PDT in our study can preferably induce ICD in 4T1, which was line with results obtained in MTT assays.

2021年8月6日 · Rapidly released DOX induces tumor ICD and elicits tumor-specific immunity, while SCH 58261 alleviates immunosuppression caused by the adenosine pathway, further enhancing DOX-induced antitumor...

2024年2月1日 · We found the addition of SLN could trigger autophagy of 4T1 cells and enhance immunogenicity initiated by DOX, hence boosting strong ICD effect. Such an LDHA-imprinted combination with autophagy-induced nano delivery system could be a promising tool for inducing ICD response and had great potential for advancing cancer immunotherapy therapeutics. .

Overall, the created FDRF NCs are able to successfully cause the ICD of 4T1 cells by the combination of chemotherapy and enhanced CDT, leading to the effective maturation of DCs in ...

Simultaneous induction of ICD and reduction of PD-L1 by the combination therapy activated antitumor immunity and suppressed immune evasion of 4T1 cells and CSCs. We believe this work helps gain more insights in the assembly of CuET based nanoparticles that is …

通过流式细胞术和图像分析评估 dox 对 4t1 的 icd 诱导。 该免疫过程进行了 3 次，在最后一次给药后，用活癌细胞的皮下异种移植物攻击免疫的小鼠。 结果： 结果表明，暴露于 DOX 后用接受 ICD 的细胞免疫的小鼠没有表现出原发性肿瘤或远处转移病灶发展的迹象。

2024年7月12日 · 细胞毒性的检测结果显示，dox和fe2o3都能够诱导4t1细胞死亡（图3c）。流式的结果显示，与pbs、dox、rpnp、rrpnp和dmsa@fe2o3相比，rrpnp@fe2o3和dppa-rrpnp@fe2o3处理的细胞都引起了明显的alexa fluor 488-crt移动，表明fe2o3和dox都诱导了icd（图3d）。

2023年11月10日 · 在三阴性乳腺癌4t1模型评估了 monp 的抗肿瘤效果，结果显示monps能够显著抑制肿瘤生长（抑制率82.71%），并提高了小鼠的生存时间。与抗pd-1抗体联合使用进一步增强抗肿瘤作用，抑制率为95.47%。值得注意的是，monps对肺转移表现出明显的抑制作用。