Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021
2021年6月3日 · Acute myeloid leukemia is a genetically heterogeneous hematologic malignancy; approximately 20% of AML harbors a mutation in the isocitrate dehydrogenase (IDH) genes, …
Characteristics and prognostic impact of IDH mutations in AML: a …
2023年10月2日 · Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this …
Impact of IDH1 and IDH2 mutation detection at diagnosis and in ...
2023年2月3日 · Multiple inhibitors targeting mutated IDH are being developed, including ivosidenib (AG-120) and enasidenib (AG-221), which have already been approved by the US …
Management of isocitrate dehydrogenase 1/2 mutated acute …
2024年4月10日 · In this review, we outline the role of IDH mutations in malignant transformation, focus in on a novel group of targeted therapeutic agents directed toward IDH1 - and IDH2 …
吴文教授：IDH1/IDH2突变AML患者生命新曙光 - 知乎
目前 IDH1靶向药 艾伏尼布 已经在我国上市，它通过与突变IDH1可逆性结合，降低肿瘤代谢物2-HG水平，促进细胞正常分化，从而发挥抗肿瘤作用，同时又可有效避免骨髓抑制、降低感染 …
Efficacy and Safety of IDH Inhibitors in AML: A Systematic Review …
2022年11月15日 · Despite improving treatment for hematological malignancies, advanced acute myeloid leukemia is associated with a poor prognosis. In this systematic review, we assessed …
The role of IDH mutations in acute myeloid leukemia - PubMed
Isocitrate dehydrogenases (IDHs) are enzymes involved in multiple metabolic and epigenetic cellular processes. Mutations in IDH1 or IDH2 are detected in approximately 20% of patients …
Characteristics and prognostic impact of IDH mutations in AML: a …
2023年10月10日 · Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this …
Blood Adv：AML中IDH突变的特征和预后影响 - 梅斯医学MedSci
2023年7月7日 · 《Blood Advances》近日发表一项研究，旨在描述 IDH 突变在不同年龄范围的大型 AML 队列中的发病率、共突变（co-occurring mutation）特征和预后影响。 作者还假设， …
Efficacy and safety of FDA-approved IDH inhibitors in the …
2023年7月11日 · We performed a comprehensive analysis of the efficacy of two IDH inhibitor regimens (IDH inhibitor combination and IDH inhibitor alone) in two populations (newly …
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