IDH是三羧酸循环的限速酶，能够催化异柠檬酸使之氧化脱羧生成α-KG和CO2。 由IDH催化的这一反应不仅是TCA循环上不可缺少的一个环节，还是细胞内NADPH/NADH等物质的重要来源之一，在细胞氧化还原平衡稳态的保持上也有着重要的作用。 此外，反应产物α-KG除了作为物质代谢的中间产物之外，在表观遗传学、蛋白质翻译后修饰等方面也具有重要的功能。 α-KG的存在对于细胞中一类叫做Fe（II）/α-ketoglutarate（α-KG）-dependent hydroxylase（翻译成中文就是“ …

Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Recurrent mutations in IDH1 or IDH2 are prevalent in several cancers including glioma, acute myeloid leukemia (AML), cholangiocarcinoma and chondrosarcoma.

2021年11月11日 · IDH1 performs its function in the cytosol, while IDH2 and IDH3 function as part of the tricarboxylic acid (TCA) cycle in the mitochondria. All three IDH isoforms catalyze the oxidative...

2024年1月29日 · 三羧酸循环（tca，也称为克雷布斯循环或柠檬酸循环）是需氧生物（原核生物和真核生物）中使用的一系列化学反应，通过氧化乙酰辅酶 a (coa) 产生能量来自碳水化合物、脂肪酸和蛋白质。

2023年7月18日 · 三羧酸（tricarboxylic acid cycle，TCA）循环，也称为柠檬酸循环或克雷布斯循环，是由一系列酶促反应组成的闭环反应。 多种代谢物进入TCA循环，构成细胞新陈代谢的中心。

2021年4月16日 · α-Ketoglutarate (α-KG), or 2-oxoglutarate, is a key TCA cycle metabolite which is generated from isocitrate by isocitrate dehydrogenase (IDH)-mediated oxidative decarboxylation of...

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are essential metabolic enzymes involved in the tricarboxylic acid (TCA) cycle. Several mutations in IDH genes have recently been described in many solid tumors, including glioma, cholangiocarcinoma, ...

Activation of the hypoxia pathway can explain SDH phenotypes, but recent data suggest that FH and IDH mutations lead to tumor formation by repressing cellular differentiation. In this review, we discuss recent findings in the context of both mitochondrial and cytoplasmic components of the TCA cycle, and we propose that extrametabolic roles of ...

2023年2月9日 · IDH突变在人类的恶性肿瘤中普遍存在，突变型的IDH酶（mutIDH）将会严重的影响细胞的生理生化反应。 第一，mutIDH将会导致细胞代谢重编，表现出TCA的氧化代谢水平增强，以及肿瘤代谢物D-2-羟戊二酸（D-2-HG）在细胞质中高浓度的积累。

2019年10月1日 · We have identified that endogenous type I IFN controls the cellular citrate/α-ketoglutarate ratio and inhibits expression and activity of isocitrate dehydrogenase (IDH); and, via 13C-labeling studies, demonstrated that autocrine type I IFN controls carbon flow through IDH in LPS-activated macrophages.