2024年12月25日 · IDH1 (Isocitrate Dehydrogenase (NADP (+)) 1) is a Protein Coding gene. Diseases associated with IDH1 include Enchondromatosis, Multiple, Ollier Type and Multiple Enchondromatosis, Maffucci Type. Among its related pathways are Nuclear events mediated by NFE2L2 and Innate Immune System.

The IDH1 gene provides instructions for making an enzyme called isocitrate dehydrogenase 1. Learn about this gene and related health conditions.

IDH1-mutated Crohn's disease-associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated-type dysplasia. Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma.

IDH1 is an enzyme located in the cytoplasm as well as in peroxisomes where it participates in lipid metabolism and glucose sensing. A number of potential hypotheses have been offered that implicate IDH1 mutations in malignant progression and oncogenesis.

2009年2月19日 · We identified mutations that affected amino acid 132 of IDH1 in more than 70% of WHO grade II and III astrocytomas and oligodendrogliomas and in glioblastomas that developed from these...

Gain of function mutations in IDH1 or IDH2 result in reduced levels of α-KG as a result of increased formation of D-2-Hydroxyglutarate (2-HG). α-KG is an essential co-factor for certain histone and DNA demethylases, while 2-HG is a competitive inhibitor.

2021年6月15日 · Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently detected in...

2025年2月9日 · Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+).

IDH1 is a dimeric cytosolic NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate (Nekrutenko et al., 1998). By RT-PCR of placenta RNA, followed by PCR of an adult liver cDNA library, Nekrutenko et al. (1998) cloned human IDH1.

2015年10月6日 · Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to &agr;-ketoglutarate (&agr;KG). IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).