然而，近50年的研究中，有一种没有特定三维结构的蛋白不断被研究人员发现，由于这类蛋白 无法折叠成稳定的三维结构 而称为 固有无序蛋白 (intrinsically disordered regions，IDRs)。 这类 …

但近50多年来，研究人员不断地发现一类新的蛋白质，它们没有明确的三维结构却具有特定生物学功能，具有无序区域的蛋白称为固有无序蛋白（IDPs）或者固有无序蛋白区域（IDRs）。 无 …

IDRs在调节转录、翻译、细胞信号转导、蛋白质磷酸化、小分子存储，以及对大的多蛋白复合体 (如细菌鞭毛及核糖体)自组装的调控等各方面都发挥着重要作用。 如我们熟知的DNA结合转录 …

2023年8月30日 · Here, we argue that IDRs are ideally poised to act as sensors and actuators of cellular physicochemistry. We review the physical principles that underlie IDR sensitivity, the …

2022年11月23日 · Both the coiled-coil 4–6 region (CC4–6) and the intrinsically disordered region (IDR) in PodJ functionally contributed to generating biomolecular condensates and forming the …

2023年8月1日 · Some subunits of TPC, such as AtEH1 and AtEH2, contain a large portion of IDR region and a coiled-coil domain for self-assembly. Many accessory proteins also contain long …

2022年8月2日 · In this work, we characterized sets of short, heterodimeric coiled-coil modules to promote the multivalency of a model IDR, the Arg/Gly-rich RGG domain of C. elegans P …

2022年4月1日 · Proteins can be intrinsically disordered fully (IDP) or have disordered regions (IDR). They provide plasticity and reversibility in binding, essential for cell signalling. There is …

2023年5月22日 · By constructing a series of mutations in charge clusters in the IDR of Ccc1, and also by removing its coiled-coil domain (which we show is a dimerization domain), we map the …

2016年9月16日 · The four main classes (Globules & Tadpoles, Coils & Hairpins, Undefined, and Swollen Coils) are shown with the number and fraction of matching long IDRs below each title. …