Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene. [5][6][7] This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines.

2024年12月25日 · IFI16 (Interferon Gamma Inducible Protein 16) is a Protein Coding gene. Diseases associated with IFI16 include Herpes Simplex and Retinoblastoma. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System.

2010年10月3日 · Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs....

2017年2月10日 · Depletion of IFI16 in macrophages impairs cGAMP production on DNA stimulation, whereas overexpression of IFI16 amplifies the function of cGAS. Furthermore, IFI16 is vital for the downstream...

2025年1月31日 · Gamma-interferon-inducible protein 16 (IFI16), recognized as an innate immune sensor for intracellular DNA 10, has been implicated in cellular senescence...

2014年12月1日 · IFI16 can sense DNA in the cytoplasm or nucleus and stimulate STING-dependent IFN expression and ASC-dependent inflammasome activation. In addition, IFI16 can also bind foreign DNA to in the nucleus and stimulate chromatin modifications leading to gene silencing. Finally IFI16 is involved in positive and negative transcriptional regulation.

Interferon-gamma inducible factor 16 (IFI16) restricts adeno-associated virus type 2 (AAV2) transduction in an immune-modulatory independent way. IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner.

2019年11月4日 · IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates cellular transcription and act as a DNA virus restriction factor. IFI16 knockdown disrupted the latency of Kaposi's sarcoma associate …

2019年7月3日 · The AIM-2-like receptors for DNA, interferon-γ-inducible protein 16 (IFI16) and Cyclic GMP-AMP synthase (cGAS) were candidate PRRs. IFI16 can detect cDNA produced during HIV-1 replication, causing increased T cell death.

Because expression of the IFI16 gene is induced by activation of DNA-damage response in cells and increased levels of IFI16 protein in cells potentiate the p53-mediated transcriptional activation of genes and p53 and pRb-mediated cell cycle arrest, we discuss how an improved understanding of the role of IFI16 protein in cellular senescence and ...