2023年11月9日 · IFN stands for Integrated Flux Nebula, and is mostly made up of space dust illuminated by all the stars in our galaxy. IFN is a term used in both scientific astronomy and astrophotography, but because it is so faint, it is mostly visible through astrophotography. IFN is often misunderstood and confused with ISM.

一旦被识别，TLR3通过β干扰素TIR结构域衔接蛋白（TRIF，也称为TICAM-1）激活转录因子干扰素调控因子3（IRF3），引起I型IFNs（尤其是IFN-β）的生成。 第二条通路涉及到TNF受体相关因子6（TRAF6）或受体相互作用蛋白1（RIP1）的募集，随后激活转录因子NF-κB 和AP-1。 这一通路的活化激发炎症因子和趋化因子表达如TNF-α，IL-6 和CXCL10。 IPoly (I:C)还能被胞质RNA解旋酶维甲酸诱导蛋白I（RIG-I）和黑色素瘤分化相关基因5（MDA-5）所识别。 1. CAS …

IDO induction by PIC, IFN- ␥ , and IFN- ␤ in primary human astrocytes. (A) Astrocyte cultures were stimulated with 10 ␮ g/ml of PIC or 10 ng/ml of recombinant IFN- ␥ or recombinant IFN-...

2014年2月25日 · 在 MEF 中，RNase L 基因敲除减少了脑心肌炎病毒感染或 poly(rI):poly(rC) (pIC) 转染对 IFN-β 的诱导。 相反，在巨噬细胞中，RNase L 缺失增加（而不是减少）病毒或 pIC 对 IFN-β 的诱导。

2017年4月24日 · IFNβ activates neuronal PI3K/Akt signalling and Akt binds to transcription factor FoxA1 that translocates to the nucleus and induces PDL1. Conversely, inhibition of PI3K/Akt, FoxA1 and PDL1 blocked...

Type I and type III interferons (IFNs) are critical for controlling viral infections. However, the precise dynamics of the IFN response have been difficult to define in vivo. Signaling through...

IFN induced 2′5′-oligoadenylate synthetase-like (OASL) limits RNA virus replication through enhancing RIG-I signaling yet inhibits cGAS and promotes viral replication for DNA viruses such as HSV. Of late, there are emergent data that SLFN proteins, non-canonical effectors of type I IFN signaling, have a role as antivirals.

The research presents experimental findings on cytokine expression and behavioral outcomes in wild-type and IFNAR1-deficient mice, highlighting the importance of IFN signaling pathways in modulating neuroinflammatory responses and associated behavioral changes.

2022年2月28日 · there is a mass of the Interflux Nebulae (IFN), and the most comprehensive coverage on those visually observable IFNs, and other very large nebulae, has been given by Mel Bartels. Some of the very large and bright IFNs can be seen even with unaided eyes, like the central part of the Polaris Flare.

2022年1月10日 · Here is the beginning of my attempt to process the IFN around M81 and M82. You really need to reach deep into the shadows to get the IFN without noise overwhelming the signal, but whatever you do to process the galactic cirr...