An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. [1] [2] Interferons bind to receptors on the surface of a cell, initiating protein signaling pathways within the cell. This interaction leads to the expression of a subset of genes involved in the innate immune system response. [1]

2018年3月1日 · Interferons (IFNs) can induce the expression of a series of interferon-stimulated genes (ISGs). As direct-acting antiviral factors, ISGs play important roles in host antiviral defense. More and more studies reveal that ISGs directly or indirectly target multiple steps of …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to …

2019年9月29日 · IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately 10% of the genes in the human genome have the potential to be regulated by IFNs. What do all of these genes do? It is a complex question without a simple answer.

ifn-γ受体（ifngr）在刺激stat1时可能具有强音活性，从而导致低水平的干扰素刺激基因（isg）表达。 该体内平衡程序平衡了免疫激活和免疫抑制。 在癌症中，高水平的IFN-γ会刺激参与免疫激活的ISG，从而抑制肿瘤的生长。

IFN induces a diverse range of antiviral effectors. Each virus has a unique, but partially overlapping, antiviral ‘ISG profile’. IFN effectors target multiple stages in the virus life cycle. The IFN signaling pathway is highly self-reinforcing. Viruses …

ifn priming是指小剂量的ifn-β就可以维持高水平的stat1/2 和 irf9，从而使免疫细胞在激活ifn信号时可以快速响应。在一些特殊的细胞类型中，i型干扰素也可以激活一些别的stat家族成员（如stat3, 4, 5a/5b,和 6）。

2019年3月4日 · Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and...

2024年10月1日 · We can distinguish between robust and tunable ISG for IFN-I. Robust ISG respond to all IFN subtypes and to low IFN doses, whereas tunable genes show variable responses to IFN-I subtypes, require higher IFN doses, and show cell type–restricted expression patterns (15, 16).

2019年3月12日 · The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signal …