Inhibition of neutrophil swarming by type I interferon promotes ...
2024年10月7日 · As expected, the JAK1/2 inhibitor Ruxolitinib rescued LTB4-induced ERK phosphorylation in the presence of IFN-I (Fig. 5j, k), and largely abolished IFN-I-mediated …
Leukotriene B4–type I interferon axis regulates macrophage …
2019年5月20日 · Here, we show that the leukotriene B 4 (LTB 4)–type I interferon (IFN) axis promotes a distinct mechanism of disease tolerance to pulmonary IAV infection. We …
Effects of leukotriene B4 on interleukin-32, interferon-γ and ...
2017年7月27日 · It has been confirmed that LTB4 is associated with expression of interleukin-1 and TNF. High concentrations of LTB4 was detected in RA patients, suggesting that LTB4 was …
Leukotriene B4-type I interferon axis regulates macrophage-mediated ...
Here, we show that the leukotriene B 4 (LTB 4)-type I interferon (IFN) axis promotes a distinct mechanism of disease tolerance to pulmonary IAV infection. We demonstrate that mice …
《自然》子刊研究揭示血源性李斯特菌固有免疫逃逸机制
2024年10月24日 · 进一步研究显示，李斯特菌会引起I型干扰素水平系统性上升，而IFN-I可通过拮抗ERK-LTB4通路抑制中性粒细胞集群反应，从而帮助李斯特菌进一步逃逸 ...
Identification of interferon-gamma as the lymphokine that …
1987年7月15日 · Recent evidence also indicates that LTB4 can directly affect the production of cytokines such as interleukin 1 (IL 1) or interleukin 2 (IL 2) and interferon-gamma (IFN …
Identification, signaling, and functions of LTB4 receptors
2017年10月1日 · Leukotriene B 4 (LTB 4), a lipid mediator produced from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We identified two receptors for LTB 4, the high …
Evaluation and interference of serum and skin lesion levels of ...
2006年7月1日 · This study found that the changing of serum LTB4 is consistent with skin lesion LTB4 and serum IFN- γ, and there are strong correlations among them. Therefore, we …
Identification of interferon-gamma as the lymphokine that …
Recent evidence also indicates that LTB4 can directly affect the production of cytokines such as interleukin 1 (IL 1) or interleukin 2 (IL 2) and interferon-gamma (IFN-gamma). In this report, we …
Mechanism of production of interferon-gamma: role of
The effects of arachidonic acid metabolites on mitogen-induced interferon (IFN)-gamma production by human peripheral blood mononuclear cells (PBMC) were examined. Both …